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A Trifluoromethyl Analogue of Celecoxib Exerts Beneficial Effects in Neuroinflammation
(Public Library of Science, 2013-12-11)
Celecoxib is a selective cyclooxygenase-2 (COX2) inhibitor. We have previously shown that celecoxib inhibits experimental autoimmune encephalomyelitis (EAE) in COX-2-deficient mice, suggestive for a mode of action involving ...
A 4-Trifluoromethyl Analogue of Celecoxib Inhibits Arthritis by Suppressing Innate Immune Cell Activation
(Biomed Central, 2012-01-17)
Introduction: Celecoxib, a highly specific cyclooxygenase-2 (COX-2) inhibitor has been reported to have COX-2-independent immunomodulatory effects. However, celecoxib itself has only mild suppressive effects on arthritis. ...