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Increased antiparkinson efficacy of the combined administration of VEGF- and GDNF-loaded nanospheres in a partial lesion model of Parkinson's disease

Herrán Martínez, Enara; Requejo Rodríguez, Catalina; Ruiz Ortega, José Ángel; Aristieta Arbelaiz, Asier; Igartua Olaechea, Manuela; Bengoetxea Odriozola, Harkaitz; Ugedo Urruela, Luisa; Pedraz Muñoz, José Luis; Lafuente Sánchez, José Vicente; Hernández Martín, Rosa María (Dove Medical Press, 2014)

Current research efforts are focused on the application of growth factors, such as glial cell line-derived neurotrophic factor (GDNF) and vascular endothelial growth factor (VEGF), as neuroregenerative approaches that will ...

Changes in Day/Night Activity in the 6-OHDA-Induced Experimental Model of Parkinson’s Disease: Exploring Prodromal Biomarkers

Requejo Rodríguez, Catalina; López de Ipiña Peña, Miren Karmele; Ruiz Ortega, José Ángel; Fernández Gómez de Segura, Elsa; Calvo Salomón, Pilar María; Morera Herreras, Teresa; Miguélez Palomo, Cristina; Cardona Grifoll, Laura; Cepeda Berenguer, Hodei; Ugedo Urruela, Luisa; Lafuente Sánchez, José Vicente (Frontiers Media, 2020-10-14)

The search for experimental models mimicking an early stage of Parkinson's disease (PD) before motor manifestations is fundamental in order to explore early signs and get a better prognosis. Interestingly, our previous ...