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Streptococcus pneumoniae , an unusual cause of early- onset neonatal sepsis and necrotizing pneumonia
(Wiley VCH, 2018-08)
Key Clinical Message Vertically transmitted sepsis due to Streptococcus pneumoniae has a low incidence, and vaginal colonization among pregnant women is exceptional. Necrotizing pneumonia is uncommon in immunocompetent ...
Identification of a panel of serum protein markers in early stage of sepsis and its validation in a cohort of patients
(Elsevier, 2018-08)
Background: Sepsis is a life-threatening illness with a challenging diagnosis. Current serum biomarkers are not sensitive enough for diagnosis. With the aim of finding proteins associated with sepsis, serum protein profile ...
Relapse patterns and outcome after relapse in standard risk medulloblastoma: a report from the HIT-SIOP-PNET4 study
(Springer, 2016-09)
The HIT-SIOP-PNET4 randomised trial for standard risk medulloblastoma (MB) (2001-2006) included 338 patients and compared hyperfractionated and conventional radiotherapy. We here report the long-term outcome after a median ...
Multicenter prospective study on the burden of rotavirus gastroenteritis in children less than 3 years of age in Spain
(Biomed Central, 2016-10-10)
Background: Rotavirus is acknowledged as an important cause of paediatric gastroenteritis worldwide. In Spain, comprehensive data on the burden of rotavirus disease was lacking.
Methods: A prospective, multicenter, ...
NMR-based newborn urine screening for optimized detection of inherited errors of metabolism
(Nature Publishing, 2019-09-10)
Inborn errors of metabolism (IEMs) are rare diseases produced by the accumulation of abnormal amounts of metabolites, toxic to the newborn. When not detected on time, they can lead to irreversible physiological and ...
Genetic and phenotypic spectrum associated with IFIH1 gain‐of‐function
(Wiley, 2020-01)
IFIH1 gain-of-function has been reported as a cause of a type I interferonopathy encompassing a spectrum of autoinflammatory phenotypes including Aicardi-Goutieres syndrome and Singleton Merten syndrome. Ascertaining ...
¿Es la transmisión vertical de Chlamydia trachomatis un problema poco reconocido en España?
(Doyma, 2019-06)
La infección por Chlamydia trachomatis es un importante problema de salud pública mundial y la principal causa bacteriana de infecciones de transmisión sexual. La infección puede transmitirse a través del canal del parto, ...
Detection of Atomic Scale Changes in the Free Volume Void Size of Three-Dimensional Colorectal Cancer Cell Culture Using Positron Annihilation Lifetime Spectroscopy
(Public Library of Science, 2014-01-02)
Positron annihilation lifetime spectroscopy (PALS) provides a direct measurement of the free volume void sizes in polymers and biological systems. This free volume is critical in explaining and understanding physical and ...
A Delphi Process to Optimize Quality and Performance of Drug Evaluation in Neonates
(Public Library Science, 2014-09-11)
Background: Neonatal trials remain difficult to conduct for several reasons: in particular the need for study sites to have an existing infrastructure in place, with trained investigators and validated quality procedures ...
Dobutamine in Paediatric Population: A Systematic Review in Juvenile Animal Models
(Public Library Science, 2014-04-22)
Objective: Although dobutamine is widely used in neonatal clinical practice, the evidence for its use in this specific population is not clear. We conducted a systematic review of the use of dobutamine in juvenile animals ...