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CGP37157, an inhibitor of the mitochondrial Na+/Ca2+ exchanger, protects neurons from excitotoxicity by blocking voltage-gated Ca2+ channels 

Ruiz Núñez, Asier; Alberdi Alfonso, Elena María; Matute Almau, Carlos José (Nature Publishing Group, 2014-04)
Inhibition of the mitochondrial Na+/Ca2+ exchanger (NCLX) by CGP37157 is protective in models of neuronal injury that involve disruption of intracellular Ca2+ homeostasis. However, the Ca2+ signaling pathways and stores ...
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Intracellular Ca2+ release through ryanodine receptors contributes to AMPA receptor-mediated mitochondrial dysfunction and ER stress in oligodendrocytes 

Ruiz Núñez, Asier; Matute Almau, Carlos José; Alberdi Alfonso, Elena María (Nature Publishing Group, 2010-07)
Overactivation of ionotropic glutamate receptors in oligodendrocytes induces cytosolic Ca2+ overload and excitotoxic death, a process that contributes to demyelination and multiple sclerosis. Excitotoxic insults cause ...
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1-42 beta-Amyloid peptide requires PDK1/nPKC/Rac 1 pathway to induce neuronal death 

Manterola, L.; Hernando Rodríguez, M.; Ruiz Núñez, Asier; Apraiz, A.; Arrizabalaga Uriarte, Oskar; Vellon, L.; Alberdi Alfonso, Elena María; Cavaliere, Fabio; Lacerda, Hadriano M.; Jimenez, S.; Parada, L. A.; Matute Almau, Carlos José; Zugaza Gurruchaga, José Luis (Nature Publishing Group, 2013-01)
1-42 beta-Amyloid (A beta(1-42)) peptide is a key molecule involved in the development of Alzheimer's disease. Some of its effects are manifested at the neuronal morphological level. These morphological changes involve ...
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Sephin1 Protects Neurons against Excitotoxicity Independently of the Integrated Stress Response 

Ruiz Núñez, Asier; Zuazo Ibarra, Jone; Ortiz Sanz, Carolina; Luchena Moreno, Celia; Matute Almau, Carlos José; Alberdi Alfonso, Elena María (MDPI, 2020-08-24)
Sephin1 is a derivative of guanabenz that inhibits the dephosphorylation of the eukaryotic initiation factor 2 alpha (eIF2α) and therefore may enhance the integrated stress response (ISR), an adaptive mechanism against ...

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Alberdi Alfonso, Elena María (4)
Matute Almau, Carlos José (4)
Ruiz Núñez, Asier (4)
Apraiz, A. (1)... View MoreDepartamento (cas.)
Neurociencias (4)
Genética, antropología física y fisiología animal (1)Departamento (eus.)Neurozientziak (4)Genetika,antropologia fisikoa eta animalien fisiologia (1)SubjectCELLULAR AND MOLECULAR NEUROSCIENCE (3)CELL BIOLOGY (2)IMMUNOLOGY AND MICROBIOLOGY (2)MEDICINE (2)... View MoreDate Issued2020 (1)2014 (1)2013 (1)2010 (1)Language(ISO)
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