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Role of Monoubiquitylation on the Control of IκBα Degradation and NF-κB Activity

Da Silva-Ferrada, Elisa; Torres-Ramos, Mónica; Aillet, Fabienne; Campagna, Michela; Matute Almau, Carlos José; Rivas, Carmen; Rodríguez Medina, Manuel Salvador (Public Library of Science, 2011-10-12)

The NF-κB pathway is regulated by multiple post-translational modifications including phosphorylation, ubiquitylation and SUMOylation. Many of these modifications act on the natural inhibitor IκBα modulating its capacity ...

GABAergic and Cortical and Subcortical Glutamatergic Axon Terminals Contain CB1 Cannabinoid Receptors in the Ventromedial Nucleus of the Hypothalamus

Reguero Acebal, Leire; Puente Bustinza, Nagore; Elezgarai Gabantxo, Izaskun; Mendizabal Zubiaga, Juan Luis; Canduela Pérez, Miren Josune; Buceta Salazar, Ianire; Ramos Uriarte, Almudena; Suárez, Juan; Rodríguez de Fonseca, Fernando; Marsicano, Giovanni; Grandes Moreno, Pedro Rolando (Public Library of Science, 2011-10)

Background: Type-1 cannabinoid receptors (CB1R) are enriched in the hypothalamus, particularly in the ventromedial hypothalamic nucleus (VMH) that participates in homeostatic and behavioral functions including food intake. ...