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Altered expression of Alzheimer's disease-related genes in the cerebellum of autistic patients: a model for disrupted brain connectome and therapy

Zeidán-Chuliá, F.; Oliveira, B-HN de; Salmina, AB; Casanova, MF; Gelain, DP; Noda, M; Verkhratsky, Alexei; Moreira, J CF (Nature Publishing Group, 2014-05)

Autism and Alzheimer's disease (AD) are, respectively, neurodevelopmental and degenerative diseases with an increasing epidemiological burden. The AD-associated amyloid-beta precursor protein-alpha has been shown to be ...

CGP37157, an inhibitor of the mitochondrial Na+/Ca2+ exchanger, protects neurons from excitotoxicity by blocking voltage-gated Ca2+ channels

Ruiz Núñez, Asier; Alberdi Alfonso, Elena María; Matute Almau, Carlos José (Nature Publishing Group, 2014-04)

Inhibition of the mitochondrial Na+/Ca2+ exchanger (NCLX) by CGP37157 is protective in models of neuronal injury that involve disruption of intracellular Ca2+ homeostasis. However, the Ca2+ signaling pathways and stores ...