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Recognition of Membrane-Bound Fusion-Peptide/MPER Complexes by the HIV-1 Neutralizing 2F5 Antibody : Implications for Anti-2F5 Immunogenicity

Huarte Arrayago, Nerea; Araujo Pasarín, Aitziber; Arranz, Rocio; Lorizate Nogales, Maier; Quendler, Heribert; Kunert, Renate; Valpuesta, José M.; Nieva Escandón, José Luis (Public Library of Science, 2012-12-21)

The membrane proximal external region (MPER) of the fusogenic HIV-1 glycoprotein-41 harbors the epitope sequence recognized by 2F5, a broadly neutralizing antibody isolated from an infected individual. Structural mimicry ...

PAnalyzer: A software tool for protein inference in shotgun proteomics

Prieto Agujeta, Gorka; Aloria Escolastico, Kerman; Osinalde Moraleja, Nerea; Fullaondo Elordui-Zapaterieche, Asier; Arizmendi Bastarrika, Jesús María; Matthiesen, Rune (BioMed Central, 2012-11-05)

Background Protein inference from peptide identifications in shotgun proteomics must deal with ambiguities that arise due to the presence of peptides shared between different proteins, which is common in higher eukaryotes. ...