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Differential activity of GSK-3 isoforms regulates NF-kappa B and TRAIL- or TNF alpha induced apoptosis in pancreatic cancer cells

Zhang, J.S.; Herreros Villanueva, Marta; Koenig, A.; Deng, Z.; M De Narvajas, A. A.; Gómez, T. S.; Meng, X.; Bujanda Fernández de Pierola, Luis; Ellenrieder, V.; Li, X. K.; Kaufmann, S. H.; Billadeau, D. D. (Nature Publishing Group, 2014-03)

While TRAIL is a promising anticancer agent due to its ability to selectively induce apoptosis in neoplastic cells, many tumors, including pancreatic ductal adenocarcinoma (PDA), display intrinsic resistance, highlighting ...