Now showing items 1-3 of 3
Functional and Metabolic Characterization of Microglia Culture in a Defined Medium
(Frontiers Media, 2020-02-07)
Microglia are the endogenous immune cells of the brain and act as sensor of infection and pathologic injury to the brain, leading to a rapid plastic process of activation that culminates in the endocytosis and phagocytosis ...
Contribution of P2X4 Receptors to CNS Function and Pathophysiology
The release and extracellular action of ATP are a widespread mechanism for cell-to-cell communication in living organisms through activation of P2X and P2Y receptors expressed at the cell surface of most tissues, including ...
P2X7 Receptors as a Therapeutic Target in Cerebrovascular Diseases
(Frontiers Media, 2020-06-18)
Shortage of oxygen and nutrients in the brain induces the release of glutamate and ATP that can cause excitotoxicity and contribute to neuronal and glial damage. Our understanding of the mechanisms of ATP release and ...