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Graphene oxide enhances alginate encapsulated cells viability and functionality while not affecting the foreign body response

Ciriza Astrain, Jesús; Sáenz del Burgo Martínez, Laura; Gurruchaga Iribar, Haritz; Borras, Francesc E.; Franquesa, Marcella; Orive Arroyo, Gorka; Hernández Martín, Rosa María; Pedraz Muñoz, José Luis (Taylor & Francis, 2018-05-21)

The combination of protein-coated graphene oxide (GO) and microencapsulation technology has moved a step forward in the challenge of improving long-term alginate encapsulated cell survival and sustainable therapeutic protein ...

Force spectroscopy-based simultaneous topographical and mechanical characterization to study polymer-to-polymer interactions in coated alginate microspheres

Virumbrales Muñoz, María; Santos Vizcaíno, Edorta; Paz, Laura; Gallardo Moreno, Amparo María; Orive Arroyo, Gorka; Hernández Martín, Rosa María; Doblaré, Manuel; González Martín, María Luisa; Fernández, Luis José; Pedraz Muñoz, José Luis; Ochoa, Ignacio (Nature Publishing, 2019-12-27)

Cell-laden hydrogel microspheres have shown encouraging outcomes in the fields of drug delivery, tissue engineering or regenerative medicine. Beyond the classical single coating with polycations, many other different coating ...

3D Printed Porous Polyamide Macrocapsule Combined with Alginate Microcapsules for Safer Cell-Based Therapies

Sáenz del Burgo Martínez, Laura; Ciriza Astrain, Jesús; Espona Noguera, Albert; Xavier, Illa; Cabruja Casas, Enric; Orive Arroyo, Gorka; Hernández Martín, Rosa María; Villa, Rosa; Pedraz Muñoz, José Luis; Álvarez, Mar (Nature Publishing Group, 2018-05-31)

Cell microencapsulation is an attractive strategy for cell-based therapies that allows the implantation of genetically engineered cells and the continuous delivery of de novo produced therapeutic products. However, the ...

Type 1 Diabetes Mellitus reversal via implantation of magnetically purified microencapsulated pseudoislets

Espona Noguera, Albert; Etxebarria Elezgarai, Jaione; Sáenz del Burgo Martínez, Laura; Cañibano Hernández, Alberto; Gurruchaga Iribar, Haritz; Blanco, Francisco Javier; Orive Arroyo, Gorka; Hernández Martín, Rosa María; Benito López, Fernando; Ciriza Astrain, Jesús; Basabe Desmonts, Lourdes; Pedraz Muñoz, José Luis (Elsevier, 2019-02-10)

Microencapsulation of pancreatic islets for the treatment of Type I Diabetes Mellitus (T1DM) generates a high quantity of empty microcapsules, resulting in high therapeutic graft volumes that can enhance the host’s immune ...

Review of Advanced Hydrogel-Based Cell Encapsulation Systems for Insulin Delivery in Type 1 Diabetes Mellitus

Espona Noguera, Albert; Ciriza Astrain, Jesús; Cañibano Hernández, Alberto; Orive Arroyo, Gorka; Hernández Martín, Rosa María; Sáenz del Burgo Martínez, Laura; Pedraz Muñoz, José Luis (MDPI, 2019-11-12)

Type 1 Diabetes Mellitus (T1DM) is characterized by the autoimmune destruction of beta-cells in the pancreatic islets. In this regard, islet transplantation aims for the replacement of the damaged beta-cells through minimally ...