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Integrated Analysis of Germline and Tumor DNA Identifies New Candidate Genes Involved in Familial Colorectal Cancer

Díaz Gay, Marcos; Franch Expósito, Sebastià; Arnau Collell, Coral; Park, Solip; Supek, Fran; Muñoz, Jenifer; Bonjoch, Laia; Gratacós Mulleras, Anna; Sánchez Rojas, Paula A.; Esteban-Jurado, Clara; Ocaña, Teresa; Cuatrecasas, Miriam; Vila Casadesús, Maria; Lozano, Juan José; Parra, Genis; Laurie, Steve; Beltran, Sergi; EPICOLON Consortium; Castells, Antoni; Bujanda Fernández de Pierola, Luis; Cubiella, Joaquín; Balaguer, Francesc; Castellví-Bel, Sergi (MDPI, 2019-03-13)

Colorectal cancer (CRC) shows aggregation in some families but no alterations in the known hereditary CRC genes. We aimed to identify new candidate genes which are potentially involved in germline predisposition to familial ...

Using linkage studies combined with whole-exome sequencing to identify novel candidate genes for familial colorectal cancer

Toma, Claudio; Díaz Gay, Marcos; Franch Expósito, Sebastià; Arnau Collell, Coral; Overs, Bronwyn; Muñoz, Jenifer; Bonjoch, Laia; Soares de Lima, Yasmin; Ocaña, Teresa; Cuatrecasas, Miriam; Castells, Antoni; Bujanda Fernández de Pierola, Luis; Balaguer, Francesc; Cubiella, Joaquín; Caldés, Trinidad; Fullerton, Janice M.; Castellví Bel, Sergi (Wiley, 2019-11)

Colorectal cancer (CRC) is a complex disorder for which the majority of the underlying germline predisposition factors remain still unidentified. Here, we combined whole-exome sequencing (WES) and linkage analysis in ...

Identification of a Novel Candidate Gene for Serrated Polyposis Syndrome Germline Predisposition by Performing Linkage Analysis Combined With Whole-Exome Sequencing

Toma, Claudio; Díaz Gay, Marcos; Soares de Lima, Yasmin; Arnau Collell, Coral; Franch Expósito, Sebastià; Muñoz, Jenifer; Overs, Bronwyn; Bonjoch, Laia; Carballal, Sabela; Ocaña, Teresa; Cuatrecasas, Miriam; Díaz de Bustamante, Aranzazu; Castells, Antoni; Bujanda Fernández de Pierola, Luis; Cubiella, Joaquín; Balaguer, Francesc; Rodríguez Alcalde, Daniel; Fullerton, Janice M.; Castellví-Bel, Sergi (Lippincott Williams & Wilkins, 2019-09-19)

OBJECTIVES: Serrated polyposis syndrome (SPS) is a complex disorder with a high risk of colorectal cancer for which the germline factors remain largely unknown. Here, we combined whole-exome sequencing (WES) and linkage ...

Analysis of A 6-Mirna Signature in Serum from Colorectal Cancer Screening Participants as Non-Invasive Biomarkers for Advanced Adenoma and Colorectal Cancer Detection

Marcuello, Maria; Duran Sanchon, Saray; Moreno, Lorena; Lozano, Juan José; Bujanda Fernández de Pierola, Luis; Castells, Antoni; Gironella, Meritxell (MDPI, 2019-10-12)

Early detection of colorectal cancer (CRC) and its precancerous lesion, advanced adenomas (AA), is critical to improve CRC incidence and prognosis. Circulating microRNAs (miRNAs or miR) are promising non-invasive biomarkers ...