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Mechanisms of action of Methylthioadenosine: pathways implicated in neuroprotection in models of Multiple Sclerosis and other neurological diseases

Moreno, B.; Di Penta, Alessandra; Kerschensteiner, M.; Matute Almau, Carlos José; Ceña, V.; López, I.; Alberch, Jordi; Parent, J.; Serra, J.; Errea, O.; Villoslada, Pablo (BioMed Central, 2010-11-25)

Background Methylthioadenosine (MTA) has anti-oxidant and anti-proliferative properties and was shown to induce cell protection in hepatic cells. We previously demonstrated that exert immunomodulatory and neuroprotective ...

Intracellular Ca2+ release through ryanodine receptors contributes to AMPA receptor-mediated mitochondrial dysfunction and ER stress in oligodendrocytes

Ruiz Núñez, Asier; Matute Almau, Carlos José; Alberdi Alfonso, Elena María (Nature Publishing Group, 2010-07)

Overactivation of ionotropic glutamate receptors in oligodendrocytes induces cytosolic Ca2+ overload and excitotoxic death, a process that contributes to demyelination and multiple sclerosis. Excitotoxic insults cause ...