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Increased antiparkinson efficacy of the combined administration of VEGF- and GDNF-loaded nanospheres in a partial lesion model of Parkinson's disease

Herrán Martínez, Enara; Requejo Rodríguez, Catalina; Ruiz Ortega, José Ángel; Aristieta Arbelaiz, Asier; Igartua Olaechea, Manuela; Bengoetxea Odriozola, Harkaitz; Ugedo Urruela, Luisa; Pedraz Muñoz, José Luis; Lafuente Sánchez, José Vicente; Hernández Martín, Rosa María (Dove Medical Press, 2014)

Current research efforts are focused on the application of growth factors, such as glial cell line-derived neurotrophic factor (GDNF) and vascular endothelial growth factor (VEGF), as neuroregenerative approaches that will ...

Low Molecular Weight Chitosan (LMWC)-based Polyplexes for pDNA Delivery: From Bench to Bedside

Agirre Díez, Mireia; Zarate Sesma, Jon; Ojeda, Edilberto; Puras Ochoa, Gustavo; Desbrieres, Jacques; Pedraz Muñoz, José Luis (MDPI, 2014-06)

Non-viral gene delivery vectors are emerging as a safer alternative to viral vectors. Among natural polymers, chitosan (Ch) is the most studied one, and low molecular weight Ch, specifically, presents a wide range of ...