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Force spectroscopy-based simultaneous topographical and mechanical characterization to study polymer-to-polymer interactions in coated alginate microspheres

Virumbrales Muñoz, María; Santos Vizcaíno, Edorta; Paz, Laura; Gallardo Moreno, Amparo María; Orive Arroyo, Gorka; Hernández Martín, Rosa María; Doblaré, Manuel; González Martín, María Luisa; Fernández, Luis José; Pedraz Muñoz, José Luis; Ochoa, Ignacio (Nature Publishing, 2019-12-27)

Cell-laden hydrogel microspheres have shown encouraging outcomes in the fields of drug delivery, tissue engineering or regenerative medicine. Beyond the classical single coating with polycations, many other different coating ...

Extracellular matrix protein microarray-based biosensor with single cell resolution: Integrin profiling and characterization of cell-biomaterial interactions

González Pujana, Ainhoa; Santos Vizcaíno, Edorta; García Hernando, Maite; Hernáez Estrada, Beatriz; Martínez de Pancorbo Gómez, María de los Angeles; Benito López, Fernando; Igartua Olaechea, Manuela; Basabe Desmonts, Lourdes; Hernández Martín, Rosa María (Elsevier, 2019-08-06)

In the search of biomaterials that promote cell adhesion, it is crucial to explore the integrin-substrate dynamic interactions given in a certain cell type to design successful biofunctionalization strategies. Here, we use ...

Type 1 Diabetes Mellitus reversal via implantation of magnetically purified microencapsulated pseudoislets

Espona Noguera, Albert; Etxebarria Elezgarai, Jaione; Sáenz del Burgo Martínez, Laura; Cañibano Hernández, Alberto; Gurruchaga Iribar, Haritz; Blanco, Francisco Javier; Orive Arroyo, Gorka; Hernández Martín, Rosa María; Benito López, Fernando; Ciriza Astrain, Jesús; Basabe Desmonts, Lourdes; Pedraz Muñoz, José Luis (Elsevier, 2019-02-10)

Microencapsulation of pancreatic islets for the treatment of Type I Diabetes Mellitus (T1DM) generates a high quantity of empty microcapsules, resulting in high therapeutic graft volumes that can enhance the host’s immune ...

Review of Advanced Hydrogel-Based Cell Encapsulation Systems for Insulin Delivery in Type 1 Diabetes Mellitus

Espona Noguera, Albert; Ciriza Astrain, Jesús; Cañibano Hernández, Alberto; Orive Arroyo, Gorka; Hernández Martín, Rosa María; Sáenz del Burgo Martínez, Laura; Pedraz Muñoz, José Luis (MDPI, 2019-11-12)

Type 1 Diabetes Mellitus (T1DM) is characterized by the autoimmune destruction of beta-cells in the pancreatic islets. In this regard, islet transplantation aims for the replacement of the damaged beta-cells through minimally ...