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Colorectal cancer molecular classification using BRAF, KRAS, microsatellite instability and CIMP status: Prognostic implications and response to chemotherapy

Murcia, Oscar; Juárez, Míriam; Rodríguez Soler, María; Hernández Illán, Eva; Giner Calabuig, Mar; Alustiza, Miren; Egoavil, Cecilia; Castillejo, Adela; Alenda, Cristina; Barberá, Víctor; Mangas Sanjuan, Carolina; Yuste, Ana; Bujanda Fernández de Pierola, Luis; Clofent, Joan; Andreu, Montserrat; Castells, Antoni; Llor, Xavier; Zapater, Pedro; Jover, Rodrigo (Public Library of Science, 2018-09-06)

Objective The aim of this study was to validate a molecular classification of colorectal cancer (CRC) based on microsatellite instability (MSI), CpG island methylator phenotype (CIMP) status, BRAF, and KRAS and investigate ...

A new approach to epigenome-wide discovery of non-invasive methylation biomarkers for colorectal cancer screening in circulating cell-free DNA using pooled samples

Gallardo-Gómez, María; Moran, Sebastian; Páez de la Cadena, María; Martínez-Zorzano, Vicenta Soledad; Rodríguez-Berrocal, Francisco Javier; Rodríguez-Girondo, Mar; Esteller, Manel; Cubiella, Joaquín; Bujanda Fernández de Pierola, Luis; Castells, Antoni; Balaguer, Francesc; Jover, Rodrigo; De Chiara, Loretta (Biomed Central, 2018-04-16)

Background: Colorectal cancer is the fourth cause of cancer-related deaths worldwide, though detection at early stages associates with good prognosis. Thus, there is a clear demand for novel non-invasive tests for the early ...

Preguntas y errores en el diagnóstico y manejo de la anemia en pacientes con hemorragia digestiva

Mearin, Fermín; Lanas, Ángel; Bujanda Fernández de Pierola, Luis; Canelles, Pilar; Cotter, José; Hervás, Antonio; Martín de Argila, Carlos; Montoro, Miguel; Gisbert, Javier P. (Elsevier, 2018-01)

A pesar de la alta prevalencia de anemia por déficit de hierro (ADH) en pacientes con hemorragia digestiva (HD) aguda o crónica, la ADH y el déficit de hierro (DH) son frecuentemente infratratados. Diversos conceptos ...

Open questions and misconceptions in the diagnosis and management of anemia in patients with gastrointestinal bleeding

Mearina, Fermín; Lanas, Ángel; Bujanda Fernández de Pierola, Luis; Canelles, Pilar; Cotter, José; Hervás, Antonio; Martín de Argila, Carlos; Montoro, Miguel; Gisbert, Javier P. (Elsevier, 2018-01)

Despite high prevalence of iron deficiency anemia (IDA) in patients with acute or chronic gastrointestinal bleeding (GIB), IDA and iron deficiency (ID) are frequently untreated. Reasons may be misconceptions about the ...

Symptom or faecal immunochemical test based referral criteria for colorectal cancer detection in symptomatic patients: a diagnostic tests study

Herrero, Jesús-Miguel; Vega, Pablo; Salve, María; Bujanda Fernández de Pierola, Luis; Cubiella, Joaquín (Biomed Central, 2018-10-25)

BackgroundSymptom based referral criteria for colorectal cancer (CRC) detection are the cornerstone of the strategy to improve prognosis in CRC. In 2017, the National Institute for Health and Care Excellence (NICE) updated ...

Extracellular Vesicles in Hepatobiliary Malignancies

Lapitz Dambolenea, Ainhoa; Arbelaiz Cossio, Ander; Olaizola, Paula; Aranburu, Aitziber; Bujanda Fernández de Pierola, Luis; Perugorria Montiel, María Jesús; Bañales Asurmendi, Jesús María (Frontiers Media, 2018-10-12)

Primary hepatobiliary malignancies include a heterogeneous group of cancers with dismal prognosis, among which hepatocellular carcinoma (HCC), cholangiocarcinoma (CCA), and hepatoblastoma (HB) stand out. These tumors mainly ...