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A novel form of human disease with a protease-sensitive prion protein and heterozygosity methionine/valine at codon 129: Case report

Rodríguez Martínez, Ana B.; Garrido, Joseba M.; Zarranz Imirizaldu, Juan José; Arteagoitia, Jose M.;; Martínez de Pancorbo Gómez, María de los Angeles; Atares, Begona;; Bilbao, Miren J.;; Ferrer, Isidro;; Juste, Ramon A.; (BioMed Central, 2010-10)

Background: Sporadic Creutzfeldt-Jakob disease (sCJD) is a rare neurodegenerative disorder in humans included in the group of Transmissible Spongiform Encephalopathies or prion diseases. The vast majority of sCJD cases are ...

Global Self-Regulation of the Cellular Metabolic Structure

Martínez de la Fuente Martínez, Ildefonso Abel; Vadillo Arroyo, Fernando; Pérez Samartín, Alberto Luis; Pérez Pinilla, Martín Blas; Bidaurrazaga Van Dierdonck, Joseba; Vera López, Antonio (Public Library of Science, 2010-03-02)

Background: Different studies have shown that cellular enzymatic activities are able to self-organize spontaneously, forming a metabolic core of reactive processes that remain active under different growth conditions while ...

Localization and Function of the Cannabinoid CB1 Receptor in the Anterolateral Bed Nucleus of the Stria Terminalis

Puente Bustinza, Nagore; Elezgarai Gabantxo, Izaskun; Lafourcade, Mathieu; Reguero Acebal, Leire; Marsicano, Giovanni; Georges, François; Manzoni, Olivier J.; Grandes Moreno, Pedro Rolando (Public Library of Science, 2010-01-25)

Background: The bed nucleus of the stria terminalis (BNST) is involved in behaviors related to natural reward, drug addiction and stress. In spite of the emerging role of the endogenous cannabinoid (eCB) system in these ...

Grafted Human Embryonic Progenitors Expressing Neurogenin-2 Stimulate Axonal Sprouting and Improve Motor Recovery after Severe Spinal Cord Injury

Perrin, Florence; Boniface, Guillaume; Serguera, Che; Lonjon, Nicolas; Serre, Angeline; Prieto, Mónica; Mallet, Jacques; Privat, Alain (Public Library of Science, 2010-12-30)

Background: Spinal cord injury (SCI) is a widely spread pathology with currently no effective treatment for any symptom. Regenerative medicine through cell transplantation is a very attractive strategy and may be used in ...

Mechanisms of action of Methylthioadenosine: pathways implicated in neuroprotection in models of Multiple Sclerosis and other neurological diseases

Moreno, B.; Di Penta, Alessandra; Kerschensteiner, M.; Matute Almau, Carlos José; Ceña, V.; López, I.; Alberch, Jordi; Parent, J.; Serra, J.; Errea, O.; Villoslada, Pablo (BioMed Central, 2010-11-25)

Background Methylthioadenosine (MTA) has anti-oxidant and anti-proliferative properties and was shown to induce cell protection in hepatic cells. We previously demonstrated that exert immunomodulatory and neuroprotective ...

Intracellular Ca2+ release through ryanodine receptors contributes to AMPA receptor-mediated mitochondrial dysfunction and ER stress in oligodendrocytes

Ruiz Núñez, Asier; Matute Almau, Carlos José; Alberdi Alfonso, Elena María (Nature Publishing Group, 2010-07)

Overactivation of ionotropic glutamate receptors in oligodendrocytes induces cytosolic Ca2+ overload and excitotoxic death, a process that contributes to demyelination and multiple sclerosis. Excitotoxic insults cause ...

Increase in the density of resting microglia precedes neuritic plaque formation and microglial activation in a transgenic model of Alzheimer's disease

Rodríguez Arellano, José Julio; Witton, J.; Olabarria, M.; Noristani, H.N.; Verkhratsky, A. (Nature Publishing Group, 2010-01)

The formation of cerebral senile plaques composed of amyloid beta peptide (A beta) is a fundamental feature of Alzheimer's disease (AD). Glial cells and more specifically microglia become reactive in the presence of A beta. ...