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Endocannabinoid long-term depression revealed at medial perforant path excitatory synapses in the dentate gyrus

Peñasco Iglesias, Sara; Rico Barrio, Irantzu; Puente Bustinza, Nagore; Gómez Urquijo, Sonia María; Fontaine, Christine J.; Egaña Huguet, Jon; Achicallende Urcaregui, Svein; Ramos Uriarte, Almudena; Reguero Acebal, Leire; Elezgarai Gabantxo, Izaskun; Nahirney, Patrick C.; Christie, Brian R.; Grandes Moreno, Pedro Rolando (Elsevier, 2019-04-22)

The endocannabinoid system modulates synaptic plasticity in the hippocampus, but a link between long-term synaptic plasticity and the type 1 cannabinoid (CB1) receptor at medial perforant path (MPP) synapses remains elusive. ...

Cannabidiol Administration Prevents Hypoxia-Ischemia-Induced Hypomyelination in Newborn Rats

Ceprián, María; Vargas, Carlos Fabián; García Toscano, Laura; Penna, Federica; Jiménez Sánchez, Laura; Achicallende Urcaregui, Svein; Elezgarai Gabantxo, Izaskun; Grandes Moreno, Pedro Rolando; Hind, William H.; Pazos Rodríguez, María Ruth; Martínez Orgado, José Antonio (Frontiers Media, 2019-09-26)

Neonatal hypoxia-ischemia (HI) is a risk factor for myelination disturbances, a key factor for cerebral palsy. Cannabidiol (CBD) protects neurons and glial cells after HI insult in newborn animals. We hereby aimed to study ...