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Muscle wasting in myotonic dystrophies: a model of premature aging

Mateos Aierdi, Alba Judith; Goicoechea, María; Aiastui, Ana; Fernández-Torrón, Roberto; García-Puga, Mikel; Matheu Fernández, Ander; López de Munain Arregui, Adolfo José (Frontiers Research Foundation, 2015-07-09)

Myotonic dystrophy type 1 (DM1 or Steinert's disease) and type 2 (DM2) are multisystem disorders of genetic origin. Progressive muscular weakness, atrophy and myotonia are the most prominent neuromuscular features of these ...

Identification of ncRNAs as Potential Therapeutic Targets in Multiple Sclerosis Through Differential ncRNA – mRNA Network Analysis

Irizar, Haritz; Muñoz Culla, Maider; Sáenz Cuesta, Matías; Osorio Querejeta, Iñaki; Sepúlveda, Lucía; Castillo Triviño, Tamara; Prada, Alvaro; López de Munain Arregui, Adolfo José; Olascoaga, Javier; Otaegui Bichot, David (Biomed Central, 2015-03-28)

Background: Several studies have revealed a potential role for both small nucleolar RNAs (snoRNAs) and microRNAs (miRNAs) in the physiopathology of relapsing-remitting multiple sclerosis (RRMS). This potential implication ...