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A 4-Trifluoromethyl Analogue of Celecoxib Inhibits Arthritis by Suppressing Innate Immune Cell Activation

Chiba, Asako; Mizuno, Miho; Tomi, Chiharu; Tajima, Ryohsuke; Alloza Moral, Iraide; Di Penta, Alessandra; Yamamura, Takashi; Vandenbroeck, Koen; Miyake, Sachiko (Biomed Central, 2012-01-17)

Introduction: Celecoxib, a highly specific cyclooxygenase-2 (COX-2) inhibitor has been reported to have COX-2-independent immunomodulatory effects. However, celecoxib itself has only mild suppressive effects on arthritis. ...