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Increased antiparkinson efficacy of the combined administration of VEGF- and GDNF-loaded nanospheres in a partial lesion model of Parkinson's disease
(Dove Medical Press, 2014)
Current research efforts are focused on the application of growth factors, such as glial cell line-derived neurotrophic factor (GDNF) and vascular endothelial growth factor (VEGF), as neuroregenerative approaches that will ...
Development of nucleic acid vaccines: use of self-amplifying RNA in lipid nanoparticles
(Dove Medical Press, 2014)
Self-amplifying RNA or RNA replicon is a form of nucleic acid-based vaccine derived from either positive-strand or negative-strand RNA viruses. The gene sequences encoding structural proteins in these RNA viruses are ...
Lipid Nanoparticles as Carriers for RNAi against Viral Infections: Current Status and Future Perspectives
(Hindawi Publishing, 2014)
The efforts made to develop RNAi-based therapies have led to productive research in the field of infections in humans, such as hepatitis C virus (HCV), hepatitis B virus (HBV), human immunodeficiency virus (HIV), human ...
Resveratrol: Anti-Obesity Mechanisms of Action
(MDPI, 2014-11)
Resveratrol is a non-flavonoid polyphenol which belongs to the stilbenes group and is produced naturally in several plants in response to injury or fungal attack. Resveratrol has been recently reported as preventing obesity. ...
Cheese consumption and prevalence of overweight and obesity in a Basque adult population: a crosssectional study
(Informa Healthcare, 2014)
[EN] Studies have reported a negative association between dairy product consumption and weight status. However, not as much research has focused on cheese; therefore, the aim of this study was to study the association ...
Complexity and Uniqueness of the Aromatic Profile of Smoked and Unsmoked Herreno Cheese
(MDPI, 2014-06)
In this work, the volatile fraction of unsmoked and smoked Herreno cheese, a type of soft cheese from the Canary Islands, has been characterized for the first time. In order to evaluate if the position in the smokehouse ...
Low Molecular Weight Chitosan (LMWC)-based Polyplexes for pDNA Delivery: From Bench to Bedside
(MDPI, 2014-06)
Non-viral gene delivery vectors are emerging as a safer alternative to viral vectors. Among natural polymers, chitosan (Ch) is the most studied one, and low molecular weight Ch, specifically, presents a wide range of ...