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Leukemia-Associated Mutations in Nucleophosmin Alter Recognition by CRM1: Molecular Basis of Aberrant Transport

Arregi Vado, Igor; Falces, Jorge; Olazabal Herrero, Ane; Alonso Mariño, Marian; Taneva, Stefka G.; Rodríguez Pérez, José Antonio; Urbaneja Arrue, María Ángeles; Bañuelos Rodríguez, Sonia (Public Library of Science, 2015-06-19)

Nucleophosmin (NPM) is a nucleocytoplasmic shuttling protein, normally enriched in nucleoli, that performs several activities related to cell growth. NPM mutations are characteristic of a subtype of acute myeloid leukemia ...

Comparison of the Transcriptional Profiles of Melanocytes from Dark and Light Skinned Individuals under Basal Conditions and Following Ultraviolet-B Irradiation

López López, Saioa; Smith Zubiaga, Isabel; García de Galdeano Zaldivar, María Alicia; Boyano López, María Dolores; García, Oscar; Gardeazábal, Jesús; Martinez-Cadenas, Conrado; Izagirre Arribalzaga, Neskuts; De la Rúa Vaca, Concepción; Alonso Alegre, Santos (Public Library Science, 2015-08-05)

We analysed the whole-genome transcriptional profile of 6 cell lines of dark melanocytes (DM) and 6 of light melanocytes (LM) at basal conditions and after ultraviolet-B (UVB) radiation at different time points to investigate ...

New Nuclear SNP Markers Unravel the Genetic Structure and Effective Population Size of Albacore Tuna (Thunnus alalunga)

Laconcha, Urtzi; Iriondo Orensanz, Mikel; Arrizabalaga, Haritz; Manzano Basabe, Carmen; Markaide Nafarrete, Pablo; Montes Asperilla, Iratxe; Zarraonaindia Martínez, Iratxe; Velado Fernández, Igor; Bilbao Castellanos, Eider; Goñi, Nicolás; Santiago, Josu; Domingo, Andrés; Karakulak, Saadet; Oray, Işık; Estomba Recalde, Miren Andone (Public Library Science, 2015-06-19)

In the present study we have investigated the population genetic structure of albacore (Thunnus alalunga, Bonnaterre 1788) and assessed the loss of genetic diversity, likely due to overfishing, of albacore population in ...

Exploring Genetic Factors Involved in Huntington Disease Age of Onset: E2F2 as a New Potential Modifier Gene

Valcárcel Ocete, Leire; Alkorta Aranburu, Gorka; Iriondo Orensanz, Mikel; Fullaondo Elordui-Zapaterieche, Asier; García-Barcina, María; Fernández-García, José Manuel; Lezcano-García, Elena; Losada-Domingo, José María; Ruiz-Ojeda, Javier; Álvarez de Arcaya, Amaia; Pérez- Ramos, José María; Roos, Raymund A. C.; Nielsen, Jørgen E.; Saft, Carsten; REGISTRY investigators of the European Huntington's Disease Network; Zubiaga Elordieta, Ana María; Aguirre Escobal, Ana Isabel (Public Library Science, 2015-07-06)

Age of onset (AO) of Huntington disease (HD) is mainly determined by the length of the CAG repeat expansion (CAGexp) in exon 1 of the HTT gene. Additional genetic variation has been suggested to contribute to AO, although ...

Ancient DNA from South-East Europe Reveals Different Events during Early and Middle Neolithic Influencing the European Genetic Heritage

Hervella Afonso, Montserrat; Rotea, Mihai; Izagirre Arribalzaga, Neskuts; Constantinescu, Mihai; Alonso Alegre, Santos; Ioana, Mihai; Lazăr, Cătălin; Ridiche, Florin; Soficaru, Andrei Dorian; Netea, Mihai G.; De la Rúa Vaca, Concepción (Public Library Science, 2015-06-08)

The importance of the process of Neolithization for the genetic make-up of European populations has been hotly debated, with shifting hypotheses from a demic diffusion (DD) to a cultural diffusion (CD) model. In this regard, ...

Genetic Variants in MiRNA Processing Genes and Pre-MiRNAs Are Associated with the Risk of Chronic Lymphocytic Leukemia

Martín Guerrero, Idoia; Gutiérrez Camino, Ángela; López López, Elixabet; Bilbao Aldaiturriaga, Nerea; Pombar Gómez, María; Ardanaz, Maite; García-Orad Carles, África (Public Library Science, 2015-03-20)

Genome wide association studies (GWAS) have identified several low-penetrance susceptibility alleles in chronic lymphocytic leukemia (CLL). Nevertheless, these studies scarcely study regions that are implicated in non-coding ...