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Antioxidant defense system and family environment in adolescents with family history of psychosis
(BioMed Central, 2012-11-16)
[EN] Our objective was to determine antioxidant defence activity in healthy controls (HC) and healthy unaffected second-degree relatives of patients with early onset psychosis (HC-FHP),and to assess its relationship with ...
A neural extracellular matrix-based method for in vitro hippocampal neuron culture and dopaminergic differentiation of neural stem cells
(BioMed Central, 2013)
Background: The ability to recreate an optimal cellular microenvironment is critical to understand neuronal
behavior and functionality in vitro. An organized neural extracellular matrix (nECM) promotes neural cell ...
Longitudinal outcome of attenuated positive symptoms, negative symptoms, functioning and remission in people at clinical high risk for psychosis: a meta-analysis
(Elsevier, 2021-06-16)
[EN] Background: Little is known about clinical outcomes other than transition to psychosis in people at Clinical High-Risk for psychosis (CHR-P). Our aim was to comprehensively meta-analytically evaluate for the first ...
Association of Notch-1, osteopontin and stem-like cells in ENU-glioma malignant process
(Impact Journals LLC, 2018-07-31)
Notch-1 and osteopontin (OPN) mediate angiogenesis and glioma stem-like cell (GSLC) maintenance. However, the relationship between these molecules and GSLCs during the development of glioma is unknown. We investigate the ...
Isolation and characterization of myogenic precursor cells from human cremaster muscle
(Nature Publishing, 2019-03-05)
Human myogenic precursor cells have been isolated and expanded from a number of skeletal muscles, but alternative donor biopsy sites must be sought after in diseases where muscle damage is widespread. Biopsy sites must be ...
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Neurological Entity?
(MDPI, 2021-09-27)
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a disorder of unknown physiopathology with multisystemic repercussions, framed in ICD-11 under the heading of neurology (8E49). There is no specific test to ...
Murine femur micro-computed tomography and biomechanical datasets for an ovariectomy-induced osteoporosis model
(Nature Research, 2021-09-15)
The development of new effective and safer therapies for osteoporosis, in addition to improved diagnostic and prevention strategies, represents a serious need in the scientific community. Micro-CT image-based analyses in ...
Glyceryl trinitrate in first-episode psychosis unmedicated with antipsychotics: A randomised controlled pilot study
(Sage, 2020-08)
There is a pressing need for new classes of treatment for psychosis. A key therapeutic target for novel compounds is the NMDA receptor, which may be modulated by nitric oxide donors such as sodium nitroprusside (SNP). ...
Universal and selective interventions to promote good mental health in young people: Systematic review and meta-analysis
(Elsevier, 2020-12)
Promotion of good mental health in young people is important. Our aim was to evaluate the consistency and magnitude of the efficacy of universal/selective interventions to promote good mental health. A systematic ...
Annual Research Review: Prevention of Psychosis in Adolescents - Systematic Review and Meta-Analysis of Advances in Detection, Prognosis and Intervention
(Wiley, 2021-05)
Background The clinical high-risk state for psychosis (CHR-P) paradigm has facilitated the implementation of psychosis prevention into clinical practice; however, advancements in adolescent CHR-P populations are less ...