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Age‐related cognitive decline in myotonic dystrophy type 1: An 11‐year longitudinal follow‐up study

Labayru Isusquiza, Garazi; Aliri Lazcano, Jone; Zulaica, Miren; López de Munain Arregui, Adolfo José; Sistiaga Berrondo, Andone (Wiley, 2020-03)

Background Myotonic dystrophy type 1 (DM1) is an inherited multi-systemic disease involving the central nervous system (CNS) and is consequently characterized by a range of cognitive impairments. However, whether this ...

Social cognition in myotonic dystrophy type 1: Specific or secondary impairment?

Labayru Isusquiza, Garazi; Arenzana, Irati; Aliri Lazcano, Jone; Zulaica, Miren; López de Munain Arregui, Adolfo José; Sistiaga Berrondo, Andone (Public Library Science, 2018-09-24)

Aims The cognitive profile of Myotonic Dystrophy type 1 (DM1) has been described in recent decades. Moreover, DM1 patients show lowered social engagement and difficulties in social-cognitive functions. The aim of the ...

Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks: The GR@ACE project

GRACE Consortium; DEGESCO Consortium; Alzheimers Dis Neuroimaging Initia; GRACE Study Grp; Martínez de Pancorbo Gómez, María de los Angeles; López de Munain Arregui, Adolfo José (Elsevier Science INC, 2019-10)

Introduction: Large variability among Alzheimer's disease (AD) cases might impact genetic discoveries and complicate dissection of underlying biological pathways. Methods: Genome Research at Fundacio ACE (GR@ACE) is a ...

Metabolic Alterations in Plasma from Patients with Familial and Idiopathic Parkinson's Disease

Yakhine Diop, Sokhna M. S.; Morales García, José A.; Niso Santano, Mireia; González Polo, Rosa A.; Uribe Carretero, Elisabet; Martínez Chacón, Guadalupe; Durand, Sylvere; Maiuri, Maria Chiara; Aiastui, Ana; Zulaica Ijurco, Miren; Ruiz Martínez, Javier; López de Munain Arregui, Adolfo José; Pérez Tur, Jordi; Pérez Castillo, Ana; Kroemer, Guido; Bravo San Pedro, José M.; Fuentes Rodríguez, José Manuel (Impact Journals LLC, 2020-09-15)

The research of new biomarkers for Parkinson's disease is essential for accurate and precocious diagnosis, as well as for the discovery of new potential disease mechanisms and drug targets. The main objective of this work ...