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Mediastinal abscess, an unusual way of presentation of eosinophilic esophagitis

Gisasola, Paul; Iriarte, Ainara; Larez, Martha Rosa; Casanova, Laura; Bujanda Fernández de Pierola, Luis (Biomed Central, 2019-02-28)

Eosinophilic esophagitis (EoE) is one of the most prevalent esophageal diseases and the leading cause of dysphagia and food impaction in children and young adults. EoE represents a chronic, local immune-mediated esophageal ...

Integrated Analysis of Germline and Tumor DNA Identifies New Candidate Genes Involved in Familial Colorectal Cancer

Díaz Gay, Marcos; Franch Expósito, Sebastià; Arnau Collell, Coral; Park, Solip; Supek, Fran; Muñoz, Jenifer; Bonjoch, Laia; Gratacós Mulleras, Anna; Sánchez Rojas, Paula A.; Esteban-Jurado, Clara; Ocaña, Teresa; Cuatrecasas, Miriam; Vila Casadesús, Maria; Lozano, Juan José; Parra, Genis; Laurie, Steve; Beltran, Sergi; EPICOLON Consortium; Castells, Antoni; Bujanda Fernández de Pierola, Luis; Cubiella, Joaquín; Balaguer, Francesc; Castellví-Bel, Sergi (MDPI, 2019-03-13)

Colorectal cancer (CRC) shows aggregation in some families but no alterations in the known hereditary CRC genes. We aimed to identify new candidate genes which are potentially involved in germline predisposition to familial ...

Pterostilbene Reduces Liver Steatosis and Modifies Hepatic Fatty Acid Profile in Obese Rats

Aguirre López, Leixuri; Palacios Ortega, Sara; Fernández Quintela, Alfredo; Hijona Muruamendiaraz, Elizabeth; Bujanda Fernández de Pierola, Luis; Portillo Baquedano, María Puy (MDPI, 2019-04-26)

Excessive fat accumulation within the liver is known as "simple hepatic steatosis", which is the most benign form of non-alcoholic fatty liver disease (NAFLD). The aim of the present study was to determine whether pterostilbene ...

Open questions and misconceptions in the diagnosis and management of anemia in patients with gastrointestinal bleeding

Mearina, Fermín; Lanas, Ángel; Bujanda Fernández de Pierola, Luis; Canelles, Pilar; Cotter, José; Hervás, Antonio; Martín de Argila, Carlos; Montoro, Miguel; Gisbert, Javier P. (Elsevier, 2018-01)

Despite high prevalence of iron deficiency anemia (IDA) in patients with acute or chronic gastrointestinal bleeding (GIB), IDA and iron deficiency (ID) are frequently untreated. Reasons may be misconceptions about the ...

Symptom or faecal immunochemical test based referral criteria for colorectal cancer detection in symptomatic patients: a diagnostic tests study

Herrero, Jesús-Miguel; Vega, Pablo; Salve, María; Bujanda Fernández de Pierola, Luis; Cubiella, Joaquín (Biomed Central, 2018-10-25)

BackgroundSymptom based referral criteria for colorectal cancer (CRC) detection are the cornerstone of the strategy to improve prognosis in CRC. In 2017, the National Institute for Health and Care Excellence (NICE) updated ...

Using linkage studies combined with whole-exome sequencing to identify novel candidate genes for familial colorectal cancer

Toma, Claudio; Díaz Gay, Marcos; Franch Expósito, Sebastià; Arnau Collell, Coral; Overs, Bronwyn; Muñoz, Jenifer; Bonjoch, Laia; Soares de Lima, Yasmin; Ocaña, Teresa; Cuatrecasas, Miriam; Castells, Antoni; Bujanda Fernández de Pierola, Luis; Balaguer, Francesc; Cubiella, Joaquín; Caldés, Trinidad; Fullerton, Janice M.; Castellví Bel, Sergi (Wiley, 2019-11)

Colorectal cancer (CRC) is a complex disorder for which the majority of the underlying germline predisposition factors remain still unidentified. Here, we combined whole-exome sequencing (WES) and linkage analysis in ...

Identification of a Novel Candidate Gene for Serrated Polyposis Syndrome Germline Predisposition by Performing Linkage Analysis Combined With Whole-Exome Sequencing

Toma, Claudio; Díaz Gay, Marcos; Soares de Lima, Yasmin; Arnau Collell, Coral; Franch Expósito, Sebastià; Muñoz, Jenifer; Overs, Bronwyn; Bonjoch, Laia; Carballal, Sabela; Ocaña, Teresa; Cuatrecasas, Miriam; Díaz de Bustamante, Aranzazu; Castells, Antoni; Bujanda Fernández de Pierola, Luis; Cubiella, Joaquín; Balaguer, Francesc; Rodríguez Alcalde, Daniel; Fullerton, Janice M.; Castellví-Bel, Sergi (Lippincott Williams & Wilkins, 2019-09-19)

OBJECTIVES: Serrated polyposis syndrome (SPS) is a complex disorder with a high risk of colorectal cancer for which the germline factors remain largely unknown. Here, we combined whole-exome sequencing (WES) and linkage ...

Gut microbiome and serum metabolome analyses identify molecular biomarkers and altered glutamate metabolism in fibromyalgia

Clos Garcia, Marc; Andrés Marín, Naiara; Fernández Eulate, Gorka; Abecia, Leticia; Lavín, José L.; Van Liemp, Sebastiaan; Cabrera, Diana; Royo, Félix; Valero, Alejandro; Errazquin, Nerea; Gómez Vega, María Cristina; Govillar, Leila; Tackett, Michael R.; Tejada, Genesis; González, Esperanza; Anguita Castillo, Juan de Dios; Bujanda Fernández de Pierola, Luis; Callejo Orcasitas, Ana María; Aransay Bañares, Ana María; Maíz, Olga; López de Munain Arregui, Adolfo José; Falcón Pérez, Juan Manuel (Elsevier, 2019-08)

Background: Fibromyalgia is a complex, relatively unknown disease characterised by chronic, widespread musculoskeletal pain. The gut-brain axis connects the gut microbiome with the brain through the enteric nervous system ...

Increased Th17-Related Cytokine Serum Levels in Patients With Multiple Polyps of Unexplained Origin

Alustiza, Miren; Hernández Illán, Eva; Juárez, Miriam; Giner Calabuig, Mar; Mira, Cristina; Martínez Roca, Alejandro; Bujanda Fernández de Pierola, Luis; Rodríguez Moranta, Francisco; Cubiella, Joaquín; De Castro, Luisa; Marín Gabriel, José Carlos; Herreros de Tejada, Alberto; Fernández Bañares, Fernando; Nicolás Pérez, David; Giménez, Paula; Martínez Cardona, Claudia; Francés, Rubén; Murcia, Oscar; Jover, Rodrigo (Wolters Kluwer, 2020-03)

OBJECTIVES: Most patients with multiple colonic polyps do not have a known genetic or hereditary origin. Our aim was to analyze the presence of inflammatory cytokines and levels of glucose, insulin, and C-reactive protein ...

Gene–Diet Interactions in Colorectal Cancer: Survey Design, Instruments, Participants and Descriptive Data of a Case–Control Study in the Basque Country

Alegría Lertxundi, Iker; Aguirre Gómez, Carmelo; Bujanda Fernández de Pierola, Luis; Fernández Pablos, Francisco Javier; Polo, Francisco; Ordovás, José María; Etxezarraga Zuluaga, María Carmen; Zabalza Estévez, Ignacio; Larzabal, Mikel; Portillo, Isabel; Martínez de Pancorbo Gómez, María de los Angeles; Palencia Madrid, Leire; García Etxebarria, Koldo; Rocandio Pablo, Ana María; Arroyo Izaga, Marta (MDPI, 2020)

Epidemiologic studies have revealed inconsistent evidence of gene-diet interaction in relation to colorectal cancer (CRC). The aim of this study was to analyze them in a sample of cases and controls from the population-based ...