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Microfluidic chip with pillar arrays for controlled production and observation of lipid membrane nanotubes
(Royal Society of Chemistry, 2020-08-07)
Lipid membrane nanotubes (NTs) are a widespread template forin vitrostudies of cellular processes happening at high membrane curvature. Traditionally NTs are manufactured one by one, using sophisticated membrane ...
Molecular Techniques for Dicistrovirus Detection without RNA Extraction or Purification
(Hindawi Publishing Corporation, 2013)
Dicistroviridae is a new family of small, nonenveloped, and +ssRNA viruses pathogenic to both beneficial arthropods and insect pests as well. Triatoma virus (TrV), a dicistrovirus, is a pathogen of Triatoma infestans ...
Multiscale modelization in a small virus: Mechanism of proton channeling and its role in triggering capsid disassembly
(Public Library Science, 2018-04)
In this work, we assess a previously advanced hypothesis that predicts the existence of ion channels in the capsid of small and non-enveloped icosahedral viruses. With this purpose we examine Triatoma Virus (TrV) as a case ...
ICTV Virus Taxonomy Profile:PolycipiviridaeIngrida
(Microbiology Society, 2019-04)
Polycipiviridae is a family of picorna-like viruses with non-segmented, linear, positive-sense RNA genomes of approximately 10-12 kb. Unusually for viruses within the order Picornavirales, their genomes are polycistronic, ...
A fluorogenic cyclic peptide for imaging and quantification of drug-induced apoptosis
(Nature, 2020-08-12)
Programmed cell death or apoptosis is a central biological process that is dysregulated in many diseases, including inflammatory conditions and cancer. The detection and quantification of apoptotic cells in vivo is hampered ...
A Computational Module Assembled from Different Protease Family Motifs Identifies PI PLC from Bacillus cereus as a Putative Prolyl Peptidase with a Serine Protease Scaffold
(Public Library Science, 2013-08)
Proteolytic enzymes have evolved several mechanisms to cleave peptide bonds. These distinct types have been systematically categorized in the MEROPS database. While a BLAST search on these proteases identifies homologous ...
Ceramide and ceramide 1-phosphate in health and disease
(BioMed Central, 2010-02)
Sphingolipids are essential components of cell membranes, and many of them regulate vital cell functions. In particular, ceramide plays crucial roles in cell signaling processes. Two major actions of ceramides are the ...
Inoculation of Triatoma Virus (Dicistroviridae: Cripavirus) elicits a non-infective immune response in mice
(Biomed Central, 2013-03)
Background: Dicistroviridae is a new family of small, non-enveloped, +ssRNA viruses pathogenic to both beneficial arthropods and insect pests. Little is known about the dicistrovirus replication mechanism or gene function, ...
Sphingomyelinase D/Ceramide 1-Phosphate in Cell Survival and Inflammation
(MDPI, 2015-05)
Sphingolipids are major constituents of biological membranes of eukaryotic cells. Many studies have shown that sphingomyelin (SM) is a major phospholipid in cell bilayers and is mainly localized to the plasma membrane of ...
The Golgi as an Assembly Line to the Autophagosome
(Elsevier, 2020-06)
Autophagy is traditionally depicted as a signaling cascade that culminates in the formation of an autophagosome that degrades cellular cargo. However, recent studies have identified myriad pathways and cellular organelles ...