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Altered expression of Alzheimer's disease-related genes in the cerebellum of autistic patients: a model for disrupted brain connectome and therapy 

Zeidán-Chuliá, F.; Oliveira, B-HN de; Salmina, AB; Casanova, MF; Gelain, DP; Noda, M; Verkhratsky, Alexei; Moreira, J CF (Nature Publishing Group, 2014-05)
Autism and Alzheimer's disease (AD) are, respectively, neurodevelopmental and degenerative diseases with an increasing epidemiological burden. The AD-associated amyloid-beta precursor protein-alpha has been shown to be ...
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Mechanisms of action of Methylthioadenosine: pathways implicated in neuroprotection in models of Multiple Sclerosis and other neurological diseases 

Moreno, B.; Di Penta, Alessandra; Kerschensteiner, M.; Matute Almau, Carlos José; Ceña, V.; López, I.; Alberch, Jordi; Parent, J.; Serra, J.; Errea, O.; Villoslada, Pablo (BioMed Central, 2010-11-25)
Background Methylthioadenosine (MTA) has anti-oxidant and anti-proliferative properties and was shown to induce cell protection in hepatic cells. We previously demonstrated that exert immunomodulatory and neuroprotective ...
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From the Cajal alumni Achucarro and Rio-Hortega to the rediscovery of never-resting microglia 

Tremblay, Marie-Ève; Lecours, Cynthia; Samson, Louis; Sánchez Zafra, Víctor; Sierra Saavedra, Amanda (Frontiers Research Foundation, 2015-04-14)
Under the guidance of Ramon y Cajal, a plethora of students flourished and began to apply his silver impregnation methods to study brain cells other than neurons: the neuroglia. In the first decades of the twentieth century, ...
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Effectiveness of a Multi-Component Smoking Cessation Support Programme (McSCSP) for Patients with Severe Mental Disorders: Study Design 

García-Portilla, María Paz; García-Álvarez, Leticia; Alejandra Saiz, Pilar; Díaz-Mesa, Eva; Galván, Gonzalo; Sarramea, Fernando; García-Blanco, Josefa; Elizagarate Zabala, Eduardo José; Bobes, Julio (MDPI, 2014-01)
Only a few studies have examined the efficacy and safety of smoking cessation programmes in patients with mental disorders. The aim of this paper is to describe in detail the methodology used in the study as well as the ...
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CGP37157, an inhibitor of the mitochondrial Na+/Ca2+ exchanger, protects neurons from excitotoxicity by blocking voltage-gated Ca2+ channels 

Ruiz Núñez, Asier; Alberdi Alfonso, Elena María; Matute Almau, Carlos José (Nature Publishing Group, 2014-04)
Inhibition of the mitochondrial Na+/Ca2+ exchanger (NCLX) by CGP37157 is protective in models of neuronal injury that involve disruption of intracellular Ca2+ homeostasis. However, the Ca2+ signaling pathways and stores ...
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Subclinical Depressive Symptoms and Continued Cannabis Use: Predictors of Negative Outcomes in First Episode Psychosis 

González Ortega, Itxaso; Alberich, Susana; Echeburúa Odriozola, Enrique; Aizpuru Barandiaran, Felipe; Millán, Eduardo; Vieta, Eduard; Matute Almau, Carlos José; González Pinto Arrillaga, Ana María (Public Library Science, 2015-04-15)
Background Although depressive symptoms in first episode psychosis have been associated with cannabis abuse, their influence on the long-term functional course of FEP patients who abuse cannabis is unknown. The aims of ...
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Pio del Rio Hortega and the discovery of the oligodendrocytes 

Pérez Cerdá, Fernando; Sánchez Gómez, María Victoria; Matute Almau, Carlos José (Frontiers Research Foundation, 2015-07-07)
Rio del Rio Hortega (1882-1945) discovered microglia and oligodendrocytes (OLGs), and after Ramon y Cajal, was the most prominent figure of the Spanish school of neurology. He began his scientific career with Nicolas ...
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Brca1 is expressed in human microglia and is dysregulated in human and animal model of ALS 

Noristani, Harun Najib; Sabourin, Jean Charles; Gerber, Yannick Nicolas; Teigell, Marisa; Sommacal, Andreas; Vivanco, Maria dM; Weber, Markus; Perrin, Florence (Biomed Central, 2015-08-01)
Background: There is growing evidence that microglia are key players in the pathological process of amyotrophic lateral sclerosis (ALS). It is suggested that microglia have a dual role in motoneurone degeneration through ...
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Is there a subgroup of long-term evolution among patients with advanced lung cancer?: Hints from the analysis of survival curves from cancer registry data 

Sánchez, Lizet; Lorenzo-Luaces, Patricia; Viada, Carmen; Galán, Yaima; Ballesteros Rodríguez, Francisco Javier; Crombet, Tania; Lage, Agustín (Biomed Central, 2014-12-11)
Background: Recently, with the access of low toxicity biological and targeted therapies, evidence of the existence of a long-term survival subpopulation of cancer patients is appearing. We have studied an unselected ...
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Number of prior episodes and the presence of depressive symptoms are associated with longer length of stay for patients with acute manic episodes 

Martín Carrasco, Manuel; González Pinto Arrillaga, Ana María; Galán, Jaime L.; Ballesteros Rodríguez, Francisco Javier; Maurino, Jorge; Vieta, Eduard (BioMed Central, 2012-03-10)
Background: Few studies have analyzed predictors of length of stay (LOS) in patients admitted due to acute bipolar manic episodes. The purpose of the present study was to estimate LOS and to determine the potential ...
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AuthorMatute Almau, Carlos José (29)López de Munain Arregui, Adolfo José (23)González Pinto Arrillaga, Ana María (22)Vandenbroeck, Koen (11)... View MoreDepartamento (cas.)
Neurociencias (162)
Biología celular e histología (4)Farmacia y ciencias de los alimentos (4)Bioquímica y biología molecular (3)... View MoreDepartamento (eus.)Neurozientziak (161)Farmazia eta elikagaien zientziak (4)Biokimika eta biologia molekularra (3)Medikuntza (3)... View MoreSubjectMEDICINE (30)BIOCHEMISTRY AND MOLECULAR BIOLOGY (23)AGRICULTURAL AND BIOLOGICAL SCIENCES (22)CELLULAR AND MOLECULAR NEUROSCIENCE (20)... View MoreDate Issued2019 (30)2018 (21)2017 (6)2016 (11)2015 (13)2014 (14)2013 (16)2012 (8)2011 (7)2010 (7)Language(ISO)eng (158)spa (4)

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