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dc.contributor.authorBujanda Fernández de Pierola, Luis
dc.contributor.authorHerreros-Villanueva, Marta
dc.date.accessioned2018-03-28T07:55:02Z
dc.date.available2018-03-28T07:55:02Z
dc.date.issued2017
dc.identifier.citationJournal of Cancer 8(18) : 3667-3674 (2016)es_ES
dc.identifier.issn1837-9664
dc.identifier.issn10.7150/jca.20750
dc.identifier.urihttp://hdl.handle.net/10810/26027
dc.description.abstractAlthough colorectal cancer (CRC) is the most common cancer type in Lynch syndrome (LS) families, patients have also increased lifetime risk of other types of tumors. The accumulated risk of pancreatic cancer (PC) in LS patients is around 3.7% and developed tumors often present a characteristically medullary appearance with prominent lymphocytic infiltration. LS patients are considered in high risk for PC development as they present 8.6-fold increase compared with the general population. Here we review PC cases reported in LS patients and current management guidelines. Literature data show that LS is clearly associated with PC and recent publications also demonstrated a connection with pancreatic neoplasic precursor lesions such as intraductal papillary mucinous neoplasms (IPMN) in these patients. While screening techniques are well established for CRC detection, clear strategies are not yet uniform for PC. Magnetic resonance imaging (MRI) and/or endoscopic ultrasound every 1-2 years in MMR mutation carriers with PC in a first or second-degree relative is recommended. Better pancreatic cancer detection strategies should be urgently defined due to the importance of early diagnosis in this disease.es_ES
dc.language.isoenges_ES
dc.publisherIvyspring International Publicactionses_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/es/*
dc.subjectcolorectal canceres_ES
dc.subjecthereditaryes_ES
dc.subjectLynch syndromees_ES
dc.subjectpancreatic canceres_ES
dc.subjectriskes_ES
dc.subjectnonpolyposes colorectal-canceres_ES
dc.subjectpapillary mucinous neoplasmes_ES
dc.subjectmismatch repair genees_ES
dc.subjectsociety task-forcees_ES
dc.subjectmicrosatellite instabilityes_ES
dc.subjectductal adenocarcinomaes_ES
dc.subjectconsensus statementes_ES
dc.subjectendometrial canceres_ES
dc.subjectincreased riskes_ES
dc.subjectfamilieses_ES
dc.titlePancreatic Cancer in Lynch Syndrome Patientses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holderIvyspring International Publisher. This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditionses_ES
dc.rights.holderAtribución-NoComercial 3.0 España*
dc.relation.publisherversionhttp://www.jcancer.org/v08p3667.htmes_ES
dc.departamentoesMedicinaes_ES
dc.departamentoeuMedikuntzaes_ES


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Ivyspring   International   Publisher.   This   is   an   open   access   article   distributed
under   the   terms   of   the   Creative   Commons   Attribution   (CC   BY-NC)   license   
(https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions
Except where otherwise noted, this item's license is described as Ivyspring International Publisher. This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions