dc.contributor.author | Labisso, Wajana L. | |
dc.contributor.author | Raulin, Ana-Caroline | |
dc.contributor.author | Nwidu, Lucky L. | |
dc.contributor.author | Kocon, Artur | |
dc.contributor.author | Wayne, Declan | |
dc.contributor.author | Erdozain Fernández, Amaia Maite | |
dc.contributor.author | Morentin Campillo, Benito | |
dc.contributor.author | Schwendener, Daniela | |
dc.contributor.author | Allen, George | |
dc.contributor.author | Enticott, Jack | |
dc.contributor.author | Gerdes, Henry K. | |
dc.contributor.author | Johnson, Laura | |
dc.contributor.author | Grzeskowiak, John | |
dc.contributor.author | Drizou, Fryni | |
dc.contributor.author | Tarbox, Rebecca | |
dc.contributor.author | Osna, Natalia A. | |
dc.contributor.author | Kharbanda, Kusum K. | |
dc.contributor.author | Callado Hernando, Luis Felipe | |
dc.contributor.author | Carter, Wayne G. | |
dc.date.accessioned | 2018-12-20T14:07:08Z | |
dc.date.available | 2018-12-20T14:07:08Z | |
dc.date.issued | 2018-09 | |
dc.identifier.citation | Brain Sciences 8(9) : (2018) // Article ID 175 | es_ES |
dc.identifier.issn | 2076-3425 | |
dc.identifier.issn | 2976-3425 | |
dc.identifier.uri | http://hdl.handle.net/10810/30473 | |
dc.description.abstract | Repetitive excessive alcohol intoxication leads to neuronal damage and brain shrinkage. We examined cytoskeletal protein expression in human post-mortem tissue from Brodmann's area 9 of the prefrontal cortex (PFC). Brain samples from 44 individuals were divided into equal groups of 11 control, 11 alcoholic, 11 non-alcoholic suicides, and 11 suicide alcoholics matched for age, sex, and post-mortem delay. Tissue from alcoholic cohorts displayed significantly reduced expression of - and -tubulins, and increased levels of acetylated -tubulin. Protein levels of histone deacetylase-6 (HDAC6), and the microtubule-associated proteins MAP-2 and MAP-tau were reduced in alcoholic cohorts, although for MAPs this was not significant. Tubulin gene expressions increased in alcoholic cohorts but not significantly. Brains from rats administered alcohol for 4 weeks also displayed significantly reduced tubulin protein levels and increased -tubulin acetylation. PFC tissue from control subjects had reduced tubulin protein expression that was most notable from the sixth to the eighth decade of life. Collectively, loss of neuronal tubulin proteins are a hallmark of both chronic alcohol consumption and natural brain ageing. The reduction of cytosolic tubulin proteins could contribute to the brain volumetric losses reported for alcoholic patients and the elderly. | es_ES |
dc.description.sponsorship | We are grateful to the following funding sources that supported this research: W.L.L. and L.L.N. were supported by University of Nottingham International Travelling Fellowships. A.M.E. was a recipient of a postdoctoral fellowship from the Basque Government. L.J. was supported by a Wellcome Trust Biomedical Summer Scholarship. A.-C.R. was supported by an European Erasmus award to work with W.G.C. L.F.C. was funded by Spanish MINECO (SAF2013-48586-R) and the Basque Government (IT616/13). Research was also in part funded by a National Institute on Alcohol Abuse and Alcoholism (NIAAA) (http://www.niaaa.nih.gov/) R21 AA017296-A1 grant (to K.K.K. and W.G.C.) and R01 AA026723-01 (to K.K.K.). The funders had no role in study design, data collection and analysis, preparation of the manuscript, or decision to publish | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/SAF2013-48586-R | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | acetylation | es_ES |
dc.subject | ageing | es_ES |
dc.subject | alcoholism | es_ES |
dc.subject | alcohol-related brain damage | es_ES |
dc.subject | -tubulin | es_ES |
dc.subject | -tubulin | es_ES |
dc.subject | HDAC6 | es_ES |
dc.subject | MAP-2 | es_ES |
dc.subject | MAP-tau | es_ES |
dc.subject | pre-frontal cortex | es_ES |
dc.subject | gray-matter | es_ES |
dc.subject | use disorders | es_ES |
dc.subject | white-matter | es_ES |
dc.subject | prefrontal cortex | es_ES |
dc.subject | cerebral-cortex | es_ES |
dc.subject | in-vivo | es_ES |
dc.subject | dependence | es_ES |
dc.subject | neuropathology | es_ES |
dc.subject | ethanol | es_ES |
dc.subject | map2 | es_ES |
dc.title | The Loss of α- and β-Tubulin Proteins Are a Pathological Hallmark of Chronic Alcohol Consumption and Natural Brain Ageing | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0). | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://www.mdpi.com/2076-3425/8/9/175 | es_ES |
dc.identifier.doi | 10.3390/brainsci8090175 | |
dc.departamentoes | Farmacología | es_ES |
dc.departamentoeu | Farmakologia | es_ES |