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dc.contributor.authorEsteban, Cristóbal
dc.contributor.authorArostegui Madariaga, Inmaculada
dc.contributor.authorAburto, Myriam
dc.contributor.authorMoraza, Javier
dc.contributor.authorQuintana, José M.
dc.contributor.authorGarcía Loizaga, Amaia
dc.contributor.authorBasualdo, Luis V.
dc.contributor.authorAramburu, Amaia
dc.contributor.authorAizpiri, Susana
dc.contributor.authorUranga, Ane
dc.contributor.authorCapelastegui, Alberto
dc.date.accessioned2019-04-17T07:54:48Z
dc.date.available2019-04-17T07:54:48Z
dc.date.issued2016-09-09
dc.identifier.citationPLOS ONE 11(9) : (2016) // Article ID e0161710es_ES
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10810/32528
dc.description.abstractBackground Although subtypes of chronic obstructive pulmonary disease are recognized, it is unknown what happens to these subtypes over time. Our objectives were to assess the stability of cluster-based subtypes in patients with stable disease and explore changes in clusters over 1 year. Methods Multiple correspondence and cluster analysis were used to evaluate data collected from 543 stable patients included consecutively from 5 respiratory outpatient clinics. Results Four subtypes were identified. Three of them, A, B, and C, had marked respiratory profiles with a continuum in severity of several variables, while the fourth, subtype D, had a more systemic profile with intermediate respiratory disease severity. Subtype A was associated with less dyspnea, better health-related quality of life and lower Charlson comorbidity scores, and subtype C with the most severe dyspnea, and poorer pulmonary function and quality of life, while subtype B was between subtypes A and C. Subtype D had higher rates of hospitalization the previous year, and comorbidities. After 1 year, all clusters remained stable. Generally, patients continued in the same subtype but 28% migrated to another cluster. Together with movement across clusters, patients showed changes in certain characteristics (especially exercise capacity, some variables of pulmonary function and physical activity) and changes in outcomes (quality of life, hospitalization and mortality) depending on the new cluster they belonged to. Conclusions Chronic obstructive pulmonary disease clusters remained stable over 1 year. Most patients stayed in their initial subtype cluster, but some moved to another subtype and accordingly had different outcomes.es_ES
dc.description.sponsorshipThis work was supported by Fondo de Investigacion Sanitaria [grant number PI020510], and by Departamento de Sanidad del Gobierno Vasco [grant number 200111002] Ministerio de Economia y Competitividad del Gobierno de Espana (MTM2013-40941-P), Departamento de Educacion, Politica Linguistica y Cultura del Gobierno Vasco (IT620-13).es_ES
dc.language.isoenges_ES
dc.publisherPublic Library Sciencees_ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/MTM2013-40941-Pes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectGeorge respiratory questionnairees_ES
dc.subjectphysical-activityes_ES
dc.subjectcluster-analysises_ES
dc.subjectclinical phenotypeses_ES
dc.subjecteclipse cohortes_ES
dc.subjectcopdes_ES
dc.subjectmortalityes_ES
dc.subjectidentificationes_ES
dc.subjectcomorbiditieses_ES
dc.subjectreliabilityes_ES
dc.titleChronic Obstructive Pulmonary Disease Subtypes. Transitions over Timees_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holder© 2016 Esteban et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.es_ES
dc.rights.holderAtribución 3.0 España*
dc.relation.publisherversionhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0161710es_ES
dc.identifier.doi10.1371/journal.pone.0161710
dc.departamentoesMatemática Aplicada, Estadística e Investigación Operativaes_ES
dc.departamentoeuMatematika aplikatua eta estatistikaes_ES


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© 2016 Esteban et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Except where otherwise noted, this item's license is described as © 2016 Esteban et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.