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Cross-Dehydrogenative Coupling Reactions for the Functionalization of α-Amino Acid Derivatives and Peptides

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Date
2018-06-25
Author
San Segundo Eizaguirre, Marcos
Correa Navarro, Arkaitz
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Synthesis 50(15) : 2853-2866 (2018)
URI
http://hdl.handle.net/10810/36647
Abstract
The functionalization of typically unreactive C(sp3)–H bondsholds great promise for reducing the reliance on existing functionalgroups while improving atom-economy and energy efficiency. As a re-sult, this topic is a matter of genuine concern for scientists in order toachieve greener chemical processes. The site-specific modification of α-amino acid and peptides based upon C(sp3)–H functionalization stillrepresents a great challenge of utmost synthetic importance. This shortreview summarizes the most recent advances in ‘Cross-Dehydrogenative Couplings’ of α-amino carbonyl compounds and peptide derivativeswith a variety of nucleophilic coupling partners.
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DSpace software copyright © 2002-2015  DuraSpace
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