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dc.contributor.authorDíaz Tajada, Esperanza
dc.contributor.authorValle García, María Blanca
dc.contributor.authorRibeiro, Sylvie
dc.contributor.authorLanceros Méndez, Senentxu
dc.contributor.authorBarandiaran García, José Manuel
dc.date.accessioned2020-02-06T18:06:07Z
dc.date.available2020-02-06T18:06:07Z
dc.date.issued2019-11-21
dc.identifier.citationMaterials 12(23) : (2019) // Article ID 3843es_ES
dc.identifier.issn1996-1944
dc.identifier.urihttp://hdl.handle.net/10810/40490
dc.description.abstractA study of Magnetite (Fe3O4)as a suitable matrix for the improved adhesion and proliferation of MC3T3-E1 pre-osteoblast cells in bone regeneration is presented. Biodegradable and magnetic polycaprolactone (PCL)/magnetite (Fe3O4) scaffolds, which were fabricated by Thermally Induced Phase Separation, are likewise analyzed. Various techniques are used to investigate in vitro degradation at 37 °C, over 104 weeks, in a phosphate buffered saline (PBS) solution. Magnetic measurements that were performed at physiological temperature (310 K) indicated that degradation neither modified the nature nor the distribution of the magnetite nanoparticles. The coercive field strength of the porous matrices demonstrated ferromagnetic behavior and the probable presence of particle interactions. The added nanoparticles facilitated the absorption of PBS, with no considerable increase in matrix degradation rates, as shown by the Gel Permeation Chromatography (GPC) results for Mw, Mn, and I. There was no collapse of the scaffold structures that maintained their structural integrity. Their suitability for bone regeneration was also supported by the absence of matrix cytotoxicity in assays, even after additions of up to 20% magnetite.es_ES
dc.description.sponsorshipThis work was supported by the Spanish Ministry of Economy and Competitiveness (MINECO) through the project MAT2016-76039-C4-3-R (AEI/FEDER, UE) and from the Basque Government Industry Department under the ELKARTEK, HAZITEK and PIBA programs. Supported by the Portuguese Foundation for Science and Technology (FCT) in the framework of the Strategic Funding UID/FIS/04650/2013, project POCI-01-0145-FEDER-028237 and grant SFRH/BD/111478/2015 (S.R.) is acknowledged.es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/MAT2016-76039-C4-3-Res_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/
dc.subjectPCLes_ES
dc.subjectmagnetitees_ES
dc.subjectscaffoldses_ES
dc.subjectmagnetismes_ES
dc.subjectcytotoxicityes_ES
dc.subjectin vitro degradationes_ES
dc.title3D Cytocompatible Composites of PCL/Magnetitees_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.date.updated2020-01-28T13:30:23Z
dc.rights.holder© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)es_ES
dc.relation.publisherversionhttps://www.mdpi.com/1996-1944/12/23/3843es_ES
dc.identifier.doi10.3390/ma12233843
dc.departamentoesElectricidad y electrónica
dc.departamentoesIngeniería Minera y Metalúrgica y Ciencia de los Materiales
dc.departamentoeuElektrizitatea eta elektronika
dc.departamentoeuMeatze eta metalurgia ingeniaritza materialen zientzia


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© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)
Except where otherwise noted, this item's license is described as © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)