Safety of Germline Genome Editing for Genetically Related ‘‘Future’’ Children as Perceived
dc.contributor.author | Ishii, Tetsuya | |
dc.contributor.author | De Miguel Beriain, Iñigo | |
dc.date.accessioned | 2020-02-28T14:17:08Z | |
dc.date.available | 2020-02-28T14:17:08Z | |
dc.date.issued | 2019-11 | |
dc.identifier.citation | CRISPR Journal 2(6) : 370-375 (2019) | es_ES |
dc.identifier.issn | 2573-1599 | |
dc.identifier.issn | 2573-1602 | |
dc.identifier.uri | http://hdl.handle.net/10810/41862 | |
dc.description.abstract | The social acceptability of germline genome editing (GGE) depends on its perceived safety, as well as respect for reproductive autonomy. However, it is doubtful that prospective parents sufficiently understand the risks of GGE. In the future, the use of GGE in specific situations seems plausible, as it offers couples potential means to safeguard genetically related future children from a serious disease and overcome infertility due to a gene mutation. Should GGE fail, however, some couples may be obliged to abort affected fetuses, or give birth to adversely affected children, which would be a tragedy. Some children might develop diseases later in life due to overlooked off-target mutations. Compounding this, some parents are unlikely to inform their offspring about the details of conception, hampering necessary follow-up. Prospective parents, scientists and policy makers should carefully discuss the safety implications of GGE for genetically related future children. | es_ES |
dc.description.sponsorship | This work was supported by the Uehiro Foundation on Ethics and Education (T.I.), the JSPS KAKENHI Project Innovative Ethics (Graduate School of Humanities, Kobe University, Kobe, Japan; T.I.), and the Government of the Basque Country (Grant IT-1066-16; I.M.B.). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Mary Ann Liebert | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | gene-therapy | es_ES |
dc.subject | abortion | es_ES |
dc.title | Safety of Germline Genome Editing for Genetically Related ‘‘Future’’ Children as Perceived | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | This Open Access article is distributed under the terms of the Creative CommonsLicense (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work isproperly cited.The CRISPR JournalVolume 2, Number 6, 2019Mary Ann Liebert, Inc.DOI: 10.1089/crispr.2019.00103 | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://www.liebertpub.com/doi/10.1089/crispr.2019.0010 | es_ES |
dc.identifier.doi | 10.1089/crispr.2019.0010 | |
dc.departamentoes | Derecho publico | es_ES |
dc.departamentoeu | Zuzenbide publikoa | es_ES |
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Except where otherwise noted, this item's license is described as This Open Access article is distributed under the terms of the Creative CommonsLicense (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work isproperly cited.The CRISPR JournalVolume 2, Number 6, 2019Mary Ann Liebert, Inc.DOI: 10.1089/crispr.2019.00103