Mobile Genetic Elements Harboring Antibiotic Resistance Determinants in Acinetobacter Baumannii Isolates from Bolivia
dc.contributor.author | Cerezales González, Mónica | |
dc.contributor.author | Xanthopoulou, Kyriaki | |
dc.contributor.author | Wille, Julia | |
dc.contributor.author | Krut, Oleg | |
dc.contributor.author | Seifert, Harald | |
dc.contributor.author | Gallego Andrés, Lucía | |
dc.contributor.author | Higgins, Paul G. | |
dc.date.accessioned | 2020-06-05T10:24:27Z | |
dc.date.available | 2020-06-05T10:24:27Z | |
dc.date.issued | 2020-05-13 | |
dc.identifier.citation | Frontiers in Microbiology 11 : (2020) // Article ID 919 | es_ES |
dc.identifier.issn | 1664-302X | |
dc.identifier.uri | http://hdl.handle.net/10810/43837 | |
dc.description.abstract | Using a combination of short- and long-read DNA sequencing, we have investigated the location of antibiotic resistance genes and characterized mobile genetic elements (MGEs) in three clinical multi-drug resistant Acinetobacter baumannii. The isolates, collected in Bolivia, clustered separately with three different international clonal lineages. We found a diverse array of transposons, plasmids and resistance islands related to different insertion sequence (IS) elements, which were located in both the chromosome and in plasmids, which conferred resistance to multiple antimicrobials, including carbapenems. Carbapenem resistance might be caused by a Tn2008 carrying the bla OXA-23 gene. Some plasmids were shared between the isolates. Larger plasmids were less conserved than smaller ones and they shared some homologous regions, while others were more diverse, suggesting that these big plasmids are more plastic than the smaller ones. The genetic basis of antimicrobial resistance in Bolivia has not been deeply studied until now, and the mobilome of these A. baumannii isolates, combined with their multi-drug resistant phenotype, mirror the transfer and prevalence of MGEs contributing to the spread of antibiotic resistance worldwide and require special attention. These findings could be useful to understand the antimicrobial resistance genetics of A. baumannii in Bolivia and the difficulty in tackling these infections. | es_ES |
dc.description.sponsorship | This work was supported by the Basque Government 1129 and University of the Basque Country [Grupo Consolidado del Sistema Universitario Vasco (IT1097-16)/UPV/EHU GIC15/143]. PH was supported by the German Research Council (DFG) – FOR2251 (www.acinetobacter.de). This work was supported by the German Center for Infection Research (DZIF). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Frontiers Media | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | baumannii | es_ES |
dc.subject | antimicrobial resistance | es_ES |
dc.subject | carbapenemase | es_ES |
dc.subject | mobile genetic | es_ES |
dc.subject | elements | es_ES |
dc.subject | plasmids | es_ES |
dc.title | Mobile Genetic Elements Harboring Antibiotic Resistance Determinants in Acinetobacter Baumannii Isolates from Bolivia | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | 2020 Cerezales, Xanthopoulou, Wille, Krut, Seifert, Gallego and Higgins. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://www.frontiersin.org/articles/10.3389/fmicb.2020.00919/full | es_ES |
dc.identifier.doi | 10.3389/fmicb.2020.00919 | |
dc.departamentoes | Inmunología, microbiología y parasitología | es_ES |
dc.departamentoeu | Immunologia, mikrobiologia eta parasitologia | es_ES |
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Except where otherwise noted, this item's license is described as 2020 Cerezales, Xanthopoulou, Wille, Krut, Seifert, Gallego and Higgins. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.