Loss of Dmrt5 Affects the Formation of the Subplate and Early Corticogenesis
dc.contributor.author | Ratié, Leslie | |
dc.contributor.author | Desmaris, Elodie | |
dc.contributor.author | García Moreno, Fernando | |
dc.contributor.author | Hoerder Suabedissen, Anna | |
dc.contributor.author | Kelman, Alexandra | |
dc.contributor.author | Theil, Thomas | |
dc.contributor.author | Bellefroid, Eric J | |
dc.contributor.author | Molnár, Zoltán | |
dc.date.accessioned | 2020-06-12T08:35:52Z | |
dc.date.available | 2020-06-12T08:35:52Z | |
dc.date.issued | 2020-05 | |
dc.identifier.citation | Cerebral Cortex 30(5) : 3296-3312 (2020) | es_ES |
dc.identifier.issn | 1047-3211 | |
dc.identifier.issn | 1460-2199 | |
dc.identifier.issn | 10.1093/cercor/bhz310 | |
dc.identifier.uri | http://hdl.handle.net/10810/43927 | |
dc.description.abstract | Dmrt5 (Dmrta2) and Dmrt3 are key regulators of cortical patterning and progenitor proliferation and differentiation. In this study, we show an altered apical to intermediate progenitor transition, with a delay in SP neurogenesis and premature birth of Ctip(2+) cortical neurons in Dmrt5(-/- )mice. In addition to the cortical progenitors, DMRT5 protein appears present in postmitotic subplate (SP) and marginal zone neurons together with some migrating cortical neurons. We observed the altered split of preplate and the reduced SP and disturbed radial migration of cortical neurons into cortical plate in Dmrt5(-/-) brains and demonstrated an increase in the proportion of multipolar cells in primary neuronal cultures from Dmrt5(-/-)embryonic brains. Dmrt5 affects cortical development with specific time sensitivity that we described in two conditional mice with slightly different deletion time. We only observed a transient SP phenotype at E15.5, but not by E18.5 after early (Dmit5(lox/lox);Emx1(Cre)) but not late (Dmrt5(lox/lox);Nestin(Cre)) deletion of Dmrt5. SP was less disturbed in Dmrt5(lox/lox);Emx1(Cre) and Dmrt3(-/- )brains than in Dmrt5(-/-) and affects dorsomedial cortex more than lateral and caudal cortex. Our study demonstrates a novel function of Dmrt5(-/-) in the regulation of early SP formation and radial cortical neuron migration. | es_ES |
dc.description.sponsorship | Collaborative grant from the Wiener-Anspach Foundation to E.J.B. and Z.M. (Role of the Dmrt5 Transcription Factor in the Development of the Earliest Cortical Circuits); work in the laboratory of E.J.B was supported by grants from the Fund for Scientific Research (FRFC 6973823, CDR 29148846); Walloon Region (First International project "NEURON"); Jean Brachet Foundation; work in the laboratory of Z.M. was funded by Medical Research Council (UK), (G00900901, MR/N026039/1); Royal Society and Anatomical Society. Work in the laboratory of T.T. was supported by the Medical Research Council (MR/K013750/1). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Oxford University Press | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | corticogenesis | es_ES |
dc.subject | dmrt | es_ES |
dc.subject | neuronal migration | es_ES |
dc.subject | subplate cajal-retzius cells | es_ES |
dc.subject | radial glial-cells | es_ES |
dc.subject | white-matter | es_ES |
dc.subject | neuronal migration | es_ES |
dc.subject | cerebral-cortex | es_ES |
dc.subject | developmental history | es_ES |
dc.subject | interstitial neurons | es_ES |
dc.subject | ganglionic eminence | es_ES |
dc.subject | postmitotic neurons | es_ES |
dc.subject | subventricular zone | es_ES |
dc.title | Loss of Dmrt5 Affects the Formation of the Subplate and Early Corticogenesis | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | The Author(s) 2019. Published by Oxford University Press.This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/),which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197206/ | es_ES |
dc.departamentoes | Neurociencias | es_ES |
dc.departamentoeu | Neurozientziak | es_ES |
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Except where otherwise noted, this item's license is described as The Author(s) 2019. Published by Oxford University Press.This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/),which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited