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dc.contributor.authorMaiz Fernández, Sheila
dc.contributor.authorPérez Álvarez, Leyre
dc.contributor.authorRuiz Rubio, Leire
dc.contributor.authorVilas Vilela, Jose Luis
dc.contributor.authorLanceros Méndez, Senentxu
dc.date.accessioned2020-10-30T11:45:39Z
dc.date.available2020-10-30T11:45:39Z
dc.date.issued2020-10-01
dc.identifier.citationPolymers 12(10) : (2020) // Article ID 2261es_ES
dc.identifier.issn2073-4360
dc.identifier.urihttp://hdl.handle.net/10810/47527
dc.description.abstractIn situ hydrogels have attracted increasing interest in recent years due to the need to develop effective and practical implantable platforms. Traditional hydrogels require surgical interventions to be implanted and are far from providing personalized medicine applications. However, in situ hydrogels offer a wide variety of advantages, such as a non-invasive nature due to their localized action or the ability to perfectly adapt to the place to be replaced regardless the size, shape or irregularities. In recent years, research has particularly focused on in situ hydrogels based on natural polysaccharides due to their promising properties such as biocompatibility, biodegradability and their ability to self-repair. This last property inspired in nature gives them the possibility of maintaining their integrity even after damage, owing to specific physical interactions or dynamic covalent bonds that provide reversible linkages. In this review, the different self-healing mechanisms, as well as the latest research on in situ self-healing hydrogels, is presented, together with the potential applications of these materials in tissue regeneration.es_ES
dc.description.sponsorshipThis research was funded by the Spanish State Research Agency (AEI) and the European Regional Development Fund (ERFD) through the project PID2019-106099RB-C43/AEI/10.13039/501100011033. Spanish Ministry of Economy and Competitiveness (MINECO) through the project MAT2016-76039-C4-3-R (AEI/FEDER, UE) and from the Basque Government Industry and Education Department under the ELKARTEK (KK-2020/00068, KK-2020/00099, KK2019/00039 and KK2019/00101), HAZITEK and PIBA (PIBA-2018-06) programs, respectively.es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/MAT2016-76039-C4-3-Res_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/
dc.subjectpolysaccharidees_ES
dc.subjectself-healinges_ES
dc.subjectin situ hydrogelses_ES
dc.subjectdynamic bondses_ES
dc.subjectinjectabilityes_ES
dc.subjecttissue engineeringes_ES
dc.titlePolysaccharide-Based In Situ Self-Healing Hydrogels for Tissue Engineering Applicationses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.date.updated2020-10-26T14:24:07Z
dc.rights.holder2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).es_ES
dc.relation.publisherversionhttps://www.mdpi.com/2073-4360/12/10/2261/htmes_ES
dc.identifier.doi10.3390/polym12102261
dc.departamentoesQuímica física
dc.departamentoeuKimika fisikoa


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2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Except where otherwise noted, this item's license is described as 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).