Show simple item record

dc.contributor.authorAbendaño Carbajo, Naiara
dc.contributor.authorBilbao Arribas, Martin
dc.contributor.authorOrtega, Maitea
dc.contributor.authorMartínez Gutiérrez, Endika
dc.contributor.authorJugo Orrantia, Begoña Marina
dc.date.accessioned2020-11-12T18:31:26Z
dc.date.available2020-11-12T18:31:26Z
dc.date.issued2020
dc.identifier.citationEkaia 38 : 141-153 (2020)
dc.identifier.issn0214-9001
dc.identifier.urihttp://hdl.handle.net/10810/47932
dc.description.abstractHamarkadak dira aluminio konposatuak txertoen laguntzaile gisa erabiltzen direla albaitaritzan eta giza txertoetan. Laguntzaile horien erabilera oso hedatua egon arren, ez da ongi ezagutzen zein mekanismoren bidez eragiten dituzten ondorio onuragarriak eta, aldizka, kontrako erreakzioak eragin ditzakete. Sistemen biologiako tekniken bidez laguntzaile hauen sinadura molekularra ikertu da, gizakietan zein etxabereetan. Hainbat eragin-mekanismo proposatu dira aluminioaren sistema immunea pizteko ahalmena azaltzeko eta analisi transkriptomikoetan erlazionatutako geneak aurkitu dira. Batzuetan emaitzak kontraesanezkoak dira, aktibatzen den erantzun immunea desberdina izan daitekeelako egoeraren arabera. Aluminiogatzen tamainak, formak, propietate fisiko-kimikoek eta antigenoen absortzioak eragina dutela ematen du era berean. Laguntzaile hauek ez dira antigeno-garraiatzaile soilak, sistema immunea kitzikatzen duten arriskuseinale endogenoak pizten baitituzte. Argitzeke dago oraindik haien eragin-mekanismo zehatza eta epe luzeko aktibazio immunitarioak sistema immunitarioaren gainestimulazioa eragin dezakeen.; Aluminium compounds have been used as adjuvants for years in veterinary and human vaccines, but, despite their widespread use, the mechanism of how aluminium-based adjuvants exert their beneficial effects is still not fully understood and they occasionally can cause adverse reactions. The molecular signature of these adjuvants has been studied by system biology techniques in human and livestock. Transcriptomic analyses have found dysregulated genes linked to some of the proposed mechanisms of action of aluminium. Sometimes the results are contradictory because the immune reaction that is activated may be different depending on the situation. The shape, size, physicochemical properties or antigen absorption of aluminium salts can also have an effect. It seems that aluminium-containing adjuvants are not simple delivery vehicles for antigens, but also induce endogenous danger signals that stimulate the immune system. Whether this contributes to long-lasting immune activation or to the overstimulation of the immune system remains to be elucidated.
dc.language.isoeus
dc.publisherServicio Editorial de la Universidad del País Vasco/Euskal Herriko Unibertsitatearen Argitalpen Zerbitzua
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.titleAluminiodun txerto-laguntzaileen eraginaren azterketa sistemen biologiaren bidez
dc.typeinfo:eu-repo/semantics/article
dc.rights.holder© 2020 UPV/EHU Attribution-NonCommercial-ShareAlike 4.0 International
dc.identifier.doi10.1387/ekaia.21400


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

© 2020 UPV/EHU Attribution-NonCommercial-ShareAlike 4.0 International
Except where otherwise noted, this item's license is described as © 2020 UPV/EHU Attribution-NonCommercial-ShareAlike 4.0 International