Is There Such a Thing as a Genuine Cancer Stem Cell Marker? Perspectives from the Gut, the Brain and the Dental Pulp
dc.contributor.author | Crende Arruabarrena, Olatz | |
dc.contributor.author | García Gallastegui, Patricia | |
dc.contributor.author | Luzuriaga González, Jon | |
dc.contributor.author | Badiola Echaburu, Iker | |
dc.contributor.author | De la Hoz Torres, Carmen | |
dc.contributor.author | Unda Rodríguez, Fernando José | |
dc.contributor.author | Ibarretxe Bilbao, Gaskon | |
dc.contributor.author | Pineda Martí, José Ramón | |
dc.date.accessioned | 2021-01-05T10:02:56Z | |
dc.date.available | 2021-01-05T10:02:56Z | |
dc.date.issued | 2020-11-27 | |
dc.identifier.citation | Biology 9(12) : (2020) // Article ID 426 | es_ES |
dc.identifier.issn | 2079-7737 | |
dc.identifier.uri | http://hdl.handle.net/10810/49638 | |
dc.description.abstract | The conversion of healthy stem cells into cancer stem cells (CSCs) is believed to underlie tumor relapse after surgical removal and fuel tumor growth and invasiveness. CSCs often arise from the malignant transformation of resident multipotent stem cells, which are present in most human tissues. Some organs, such as the gut and the brain, can give rise to very aggressive types of cancers, contrary to the dental pulp, which is a tissue with a very remarkable resistance to oncogenesis. In this review, we focus on the similarities and differences between gut, brain and dental pulp stem cells and their related CSCs, placing a particular emphasis on both their shared and distinctive cell markers, including the expression of pluripotency core factors. We discuss some of their similarities and differences with regard to oncogenic signaling, telomerase activity and their intrinsic propensity to degenerate to CSCs. We also explore the characteristics of the events and mutations leading to malignant transformation in each case. Importantly, healthy dental pulp stem cells (DPSCs) share a great deal of features with many of the so far reported CSC phenotypes found in malignant neoplasms. However, there exist literally no reports about the contribution of DPSCs to malignant tumors. This raises the question about the particularities of the dental pulp and what specific barriers to malignancy might be present in the case of this tissue. These notable differences warrant further research to decipher the singular properties of DPSCs that make them resistant to transformation, and to unravel new therapeutic targets to treat deadly tumors. | es_ES |
dc.description.sponsorship | This work has been financed by The University of The Basque Country (UPV/EHU): Grant number GIU16/66, UFI 11/44, COLAB19/03 and IKERTU-2020.0155 (to F.U), the Basque Government/Eusko Jaurkaritza: ELKARTEK KK-2019/00093 (to U.F.), and MINECO “Ramón y Cajal” program RYC-2013-13450 and MINECO PID2019-104766RB-C21 (to P.J.R.). L.J. was funded by a UPV/EHU postdoctoral fellowship DOKBERRI 2019 (DOCREC19/49) program. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/RYC-2013-13450 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/PID2019-104766RB-C21 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | |
dc.subject | stem cells | es_ES |
dc.subject | cancer stem cells | es_ES |
dc.subject | dental pulp stem cells | es_ES |
dc.subject | glioma | es_ES |
dc.subject | colorectal cancer | es_ES |
dc.subject | cell markers | es_ES |
dc.subject | telomerase | es_ES |
dc.subject | alternative lengthening of telomeres | es_ES |
dc.subject | pluripotency core factors | es_ES |
dc.title | Is There Such a Thing as a Genuine Cancer Stem Cell Marker? Perspectives from the Gut, the Brain and the Dental Pulp | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.date.updated | 2020-12-24T15:54:43Z | |
dc.rights.holder | 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/2079-7737/9/12/426/htm | es_ES |
dc.identifier.doi | 10.3390/biology9120426 | |
dc.departamentoes | Biología celular e histología | |
dc.departamentoeu | Zelulen biologia eta histologia |
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Except where otherwise noted, this item's license is described as 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).