dc.contributor.author | Guerrero Azurmendi, Itziar | |
dc.contributor.author | Correa Navarro, Arkaitz | |
dc.date.accessioned | 2021-01-14T18:33:32Z | |
dc.date.available | 2021-01-14T18:33:32Z | |
dc.date.issued | 2020-02-13 | |
dc.identifier.citation | Organic Letters 22(5) : 1754-1759 (2020) | es_ES |
dc.identifier.issn | 1523-7060 | |
dc.identifier.uri | http://hdl.handle.net/10810/49766 | |
dc.description.abstract | Site-selective functionalization of C–H bonds within a peptide framework poses a challenging task of paramount synthetic relevance. Herein, we report an operationally simple C(sp2)–H trifluoromethylation of tryptophan (Trp)-containing peptides. This fluorination technique is characterized by its chirality preservation, tolerance of functional groups, and scalability and exhibits chemoselectivity for Trp residues over other amino acid and heterocyclic units. As a result, it represents a sustainable tool toward the late-stage peptide modification and protein engineering. | es_ES |
dc.description.sponsorship | We are grateful to MINECO (RTI2018-093721-B-I00) and the Basque Government (IT1033-16) for financial support. I.G. thanks the Basque Government for a predoctoral fellowship. We are thankful for technical and human support provided by SGIker of UPV/EHU and European funding (ERDF and ESF). Cost-CHAOS action (CA15106) is also acknowledged. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | ACS Publications | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/RTI2018-093721-B-I00 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | trifluoromethylation | es_ES |
dc.subject | peptides | es_ES |
dc.subject | tryptophan | es_ES |
dc.title | Cu-Catalyzed Site-Selective C(sp2)–H Radical Trifluoromethylation of Tryptophan Containing Peptides | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2020 American Chemical Society | es_ES |
dc.relation.publisherversion | https://pubs.acs.org/doi/10.1021/acs.orglett.0c00033 | es_ES |
dc.identifier.doi | 10.1021/acs.orglett.0c00033 | |
dc.departamentoes | Química orgánica I | es_ES |
dc.departamentoeu | Kimika organikoa I | es_ES |