Linking Plasma Amyloid Beta and Neurofilament Light Chain to Intracortical Myelin Content in Cognitively Normal Older Adults
dc.contributor.author | Fernández Álvarez, Marina | |
dc.contributor.author | Atienza, Mercedes | |
dc.contributor.author | Zallo, Fátima | |
dc.contributor.author | Matute Almau, Carlos José | |
dc.contributor.author | Capetillo González de Zarate, Estibaliz | |
dc.contributor.author | Cantero, José Luis | |
dc.date.accessioned | 2022-09-13T16:53:50Z | |
dc.date.available | 2022-09-13T16:53:50Z | |
dc.date.issued | 2022-06 | |
dc.identifier.citation | Frontiers in Aging Neuroscience 14 : (2022) // Article ID 896848 | es_ES |
dc.identifier.issn | 1663-4365 | |
dc.identifier.uri | http://hdl.handle.net/10810/57724 | |
dc.description.abstract | Evidence suggests that lightly myelinated cortical regions are vulnerable to aging and Alzheimer's disease (AD). However, it remains unknown whether plasma markers of amyloid and neurodegeneration are related to deficits in intracortical myelin content, and whether this relationship, in turn, is associated with altered patterns of resting-state functional connectivity (rs-FC). To shed light into these questions, plasma levels of amyloid-beta fragment 1-42 (A beta(1-42)) and neurofilament light chain (NfL) were measured using ultra-sensitive single-molecule array (Simoa) assays, and the intracortical myelin content was estimated with the ratio T1-weigthed/T2-weighted (T1w/T2w) in 133 cognitively normal older adults. We assessed: (i) whether plasma A beta(1-42) and/or NfL levels were associated with intracortical myelin content at different cortical depths and (ii) whether cortical regions showing myelin reductions also exhibited altered rs-FC patterns. Surface-based multiple regression analyses revealed that lower plasma A beta(1-42) and higher plasma NfL were associated with lower myelin content in temporo-parietal-occipital regions and the insular cortex, respectively. Whereas the association with A beta(1-42) decreased with depth, the NfL-myelin relationship was most evident in the innermost layer. Older individuals with higher plasma NfL levels also exhibited altered rs-FC between the insula and medial orbitofrontal cortex. Together, these findings establish a link between plasma markers of amyloid/neurodegeneration and intracortical myelin content in cognitively normal older adults, and support the role of plasma NfL in boosting aberrant FC patterns of the insular cortex, a central brain hub highly vulnerable to aging and neurodegeneration. | es_ES |
dc.description.sponsorship | This work was supported by the Spanish Ministry of Economy and Competitiveness (PID2020-119978RB-I00 to JLC and PID2020-118825GB-I00 to MA), CIBERNED (JLC, MA, CM, EC-Z, and FZ), Alzheimers Association (AARG-NFT-22-924702 to JLC), the Basque Government (IT1203-19; ELKARTEK KK-2020/00034 to EC-Z), the Research Program for a Long-Life Society of the Fundacion General CSIC (0551_PSL_6_E to JLC), the Junta de Andalucia (PY20_00858 to JLC), and the Andalucia-FEDER Program (UPO-1380913 to JLC). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Frontiers Media | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/PID2020-119978RB-I00 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/PID2020-118825GB-I00 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | aging | es_ES |
dc.subject | Alzheimer's disease | es_ES |
dc.subject | intracortical myelin | es_ES |
dc.subject | functional connectivity | es_ES |
dc.subject | blood biomarkers | es_ES |
dc.subject | amyloid-beta | es_ES |
dc.subject | neurofilament light | es_ES |
dc.title | Linking Plasma Amyloid Beta and Neurofilament Light Chain to Intracortical Myelin Content in Cognitively Normal Older Adults | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2022 Fernandez-Alvarez, Atienza, Zallo, Matute, Capetillo-Zarate and Cantero. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://www.frontiersin.org/articles/10.3389/fnagi.2022.896848/full | es_ES |
dc.identifier.doi | 10.3389/fnagi.2022.896848 | |
dc.departamentoes | Neurociencias | es_ES |
dc.departamentoeu | Neurozientziak | es_ES |
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