dc.contributor.author | Battal, Ceren | |
dc.contributor.author | Gurtubay-Antolin, Ane | |
dc.contributor.author | Rezk, Mohamed | |
dc.contributor.author | Mattioni, Stefania | |
dc.contributor.author | Bertonati, Giorgia | |
dc.contributor.author | Occelli, Valeria | |
dc.contributor.author | Bottini, Roberto | |
dc.contributor.author | Targher, Stefano | |
dc.contributor.author | Maffei, Chiara | |
dc.contributor.author | Jovicich, Jorge | |
dc.contributor.author | Collignon, Olivier | |
dc.date.accessioned | 2022-10-17T10:52:54Z | |
dc.date.available | 2022-10-17T10:52:54Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Battal C, Gurtubay-Antolin A, Rezk M, Mattioni S, Bertonati G, Occelli V, Bottini R, Targher S, Maffei C, Jovicich J, Collignon O. Structural and Functional Network-Level Reorganization in the Coding of Auditory Motion Directions and Sound Source Locations in the Absence of Vision. J Neurosci. 2022 Jun 8;42(23):4652-4668. doi: 10.1523/JNEUROSCI.1554-21.2022. Epub 2022 May 2. PMID: 35501150; PMCID: PMC9186796 | es_ES |
dc.identifier.citation | JNEUROSCI THE JOURNAL OF NEUROSCIENCE | |
dc.identifier.issn | 0270-6474 | |
dc.identifier.uri | http://hdl.handle.net/10810/58042 | |
dc.description | Epub 2022 May 2 | es_ES |
dc.description.abstract | hMT+/V5 is a region in the middle occipitotemporal cortex that responds preferentially to visual motion in sighted people. In cases of early visual deprivation, hMT+/V5 enhances its response to moving sounds. Whether hMT+/V5 contains information about motion directions and whether the functional enhancement observed in the blind is motion specific, or also involves sound source location, remains unsolved. Moreover, the impact of this cross-modal reorganization of hMT+/V5 on the regions typically supporting auditory motion processing, like the human planum temporale (hPT), remains equivocal. We used a combined functional and diffusion-weighted MRI approach and individual in-ear recordings to study the impact of early blindness on the brain networks supporting spatial hearing in male and female humans. Whole-brain univariate analysis revealed that the anterior portion of hMT+/V5 responded to moving sounds in sighted and blind people, while the posterior portion was selective to moving sounds only in blind participants. Multivariate decoding analysis revealed that the presence of motion direction and sound position information was higher in hMT+/V5 and lower in hPT in the blind group. While both groups showed axis-of-motion organization in hMT+/V5 and hPT, this organization was reduced in the hPT of blind people. Diffusion-weighted MRI revealed that the strength of hMT+/V5-hPT connectivity did not differ between groups, whereas the microstructure of the connections was altered by blindness. Our results suggest that the axis-of-motion organization of hMT+/V5 does not depend on visual experience, but that congenital blindness alters the response properties of occipitotemporal networks supporting spatial hearing in the sighted.SIGNIFICANCE STATEMENT Spatial hearing helps living organisms navigate their environment. This is certainly even more true in people born blind. How does blindness affect the brain network supporting auditory motion and sound source location? Our results show that the presence of motion direction and sound position information was higher in hMT+/V5 and lower in human planum temporale in blind relative to sighted people; and that this functional reorganization is accompanied by microstructural (but not macrostructural) alterations in their connections. These findings suggest that blindness alters cross-modal responses between connected areas that share the same computational goals. | es_ES |
dc.description.sponsorship | The project was funded in part by a European Research Council starting grant MADVIS (Project
337573) awarded to O.C., the Belgian Excellence of Science (EOS) program (Project 30991544)
awarded to O.C., a Flagship ERA-NET grant SoundSight (FRS-FNRS PINT-MULTI R.8008.19) awarded to
O.C., and by the European Union Horizon 2020 research and innovation program under the Marie
Skłodowska-Curie Grant Agreement No. 701250 awarded to V.O. Computational resources have been
provided by the supercomputing facilities of the Université catholique de Louvain (CISM/UCL) and
the Consortium des Équipements de Calcul Intensif en Fédération Wallonie Bruxelles (CÉCI) funded
by the Fond de la Recherche Scientifique de Belgique (F.R.S.-FNRS) under convention 2.5020.11 and
by the Walloon Region. A.G.-A. is supported by the Wallonie Bruxelles International Excellence
Fellowship and the FSR Incoming PostDoc Fellowship by Université Catholique de Louvain. O.C. is a
research associate, C.B. is postdoctoral researcher, and M.R. is a research fellow at the Fond National
de la Recherche Scientifique de Belgique (FRS-FNRS). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Jneurosci | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/ERC-337573 | |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/MC/701250 | |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Planum Temporale | es_ES |
dc.subject | auditory space | es_ES |
dc.subject | blindness | es_ES |
dc.subject | crossmodal plasticity | es_ES |
dc.subject | hMT+/V5 | es_ES |
dc.subject | tractography | es_ES |
dc.title | Structural and Functional Network-Level Reorganization in the Coding of Auditory Motion Directions and Sound Source Locations in the Absence of Vision | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | Copyright © 2022 the authors. | es_ES |
dc.relation.publisherversion | https://www.jneurosci.org/ | es_ES |
dc.identifier.doi | 10.1523/JNEUROSCI.1554-21.2022 | |