Dysautonomia and small fiber neuropathy in post-COVID condition and Chronic Fatigue Syndrome
dc.contributor.author | Azcue González, Naiara | |
dc.contributor.author | Del Pino Sáez, Rocío | |
dc.contributor.author | Acera Gil, María Ángeles | |
dc.contributor.author | Fernández Valle, Tamara | |
dc.contributor.author | Ayo Mentxakatorre, Naia | |
dc.contributor.author | Pérez Concha, Tomás | |
dc.contributor.author | Murueta-Goyena Larrañaga, Ane | |
dc.contributor.author | Lafuente Sánchez, José Vicente | |
dc.contributor.author | Prada, Alvaro | |
dc.contributor.author | López de Munain Arregui, Adolfo José | |
dc.contributor.author | Ruiz Irastorza, Guillermo | |
dc.contributor.author | Martín Iglesias, Daniel | |
dc.contributor.author | Ribacoba, Laureano | |
dc.contributor.author | Gabilondo Cuellar, Iñigo | |
dc.contributor.author | Gómez Esteban, Juan Carlos | |
dc.contributor.author | Tijero Merino, Beatriz | |
dc.date.accessioned | 2024-05-03T17:22:09Z | |
dc.date.available | 2024-05-03T17:22:09Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Journal of Translational Medicine 21 : (2023) // Article ID 814 | es_ES |
dc.identifier.issn | 1479-5876 | |
dc.identifier.uri | http://hdl.handle.net/10810/67469 | |
dc.description.abstract | Background Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and post-COVID condition can present similarities such as fatigue, brain fog, autonomic and neuropathic symptoms. Methods The study included 87 patients with post-COVID condition, 50 patients with ME/CFS, and 50 healthy controls (HC). The hemodynamic autonomic function was evaluated using the deep breathing technique, Valsalva maneuver, and Tilt test. The presence of autonomic and sensory small fiber neuropathy (SFN) was assessed with the Sudoscan and with heat and cold evoked potentials, respectively. Finally, a complete neuropsychological evaluation was performed. The objective of this study was to analyze and compare the autonomic and neuropathic symptoms in post-COVID condition with ME/CFS, and HC, as well as, analyze the relationship of these symptoms with cognition and fatigue. Results Statistically significant differences were found between groups in heart rate using the Kruskal–Wallis test (H), with ME/CFS group presenting the highest (H = 18.3; p ≤ .001). The Postural Orthostatic Tachycardia Syndrome (POTS), and pathological values in palms on the Sudoscan were found in 31% and 34% of ME/CFS, and 13.8% and 19.5% of post-COVID patients, respectively. Concerning evoked potentials, statistically significant differences were found in response latency to heat stimuli between groups (H = 23.6; p ≤ .01). Latency was highest in ME/CFS, and lowest in HC. Regarding cognition, lower parasympathetic activation was associated with worse cognitive performance. Conclusions Both syndromes were characterized by inappropriate tachycardia at rest, with a high percentage of patients with POTS. The prolonged latencies for heat stimuli suggested damage to unmyelinated fibers. The higher proportion of patients with pathological results for upper extremities on the Sudoscan suggested a non-length-dependent SFN. | es_ES |
dc.description.sponsorship | This study has been funded by Instituto de Salud Carlos III (ISCIII) through the project PI20/01076 and co‑funded by the European Union, EITB maratoia (BIOS21/COV/006) and grants for health research projects from the Basque Government (2021111006). Azcue, N. received a pre‑doctoral research grant from the basque government (PRE_2022_2_0111). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | BMC | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | cognition | es_ES |
dc.subject | dysautonomia | es_ES |
dc.subject | myalgic encephalomyelitis/chronic fatigue syndrome | es_ES |
dc.subject | post‑COVID condition | es_ES |
dc.subject | small fiber neuropathy | es_ES |
dc.title | Dysautonomia and small fiber neuropathy in post-COVID condition and Chronic Fatigue Syndrome | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativeco mmons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-023-04678-3 | es_ES |
dc.identifier.doi | 10.1186/s12967-023-04678-3 | |
dc.departamentoes | Neurociencias | es_ES |
dc.departamentoeu | Neurozientziak | es_ES |
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mmons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.