dc.contributor.author | Muñoa Hoyos, Iraia | |
dc.contributor.author | Araolaza Lasa, Manu | |
dc.contributor.author | Urizar Arenaza, Itziar | |
dc.contributor.author | Gianzo Citores, Marta | |
dc.contributor.author | Irazusta Astiazaran, Jon | |
dc.contributor.author | Subirán Ciudad, Nerea | |
dc.date.accessioned | 2024-05-22T14:40:59Z | |
dc.date.available | 2024-05-22T14:40:59Z | |
dc.date.issued | 2021-06 | |
dc.identifier.citation | Food and Chemical Toxicology 152 : (2021) // Article ID 112200 | es_ES |
dc.identifier.issn | 0278-6915 | |
dc.identifier.issn | 1873-6351 | |
dc.identifier.uri | http://hdl.handle.net/10810/68097 | |
dc.description.abstract | Epigenetic marks may be also affected by several factors, such as age, lifestyle, early life experiences and exposure to chemicals or drugs, such as opioids. Previous studies have focused on how morphine epigenetically regulates different regions of the brain that are implicated in tolerance, dependence and other psychiatric disorders more related to the physio-pathological effects of opioids. Nevertheless, a significant knowledge gap remains regarding the effect of chronic treatment on other organs and biological systems. Therefore, the aim of this work is to increase our knowledge about the impact of chronic morphine exposure on DNA methylation and histone modification levels in each of the organs of male and female model mice in vivo. Our results reveal, for the first time, that chronic morphine treatment induced changes in DNA methylation/hydroxymethylation and histone modification in-vivo at the systemic level, revealing a potential physiological effect on the regulation of gene expression. Notably, morphine-induced epigenetic modification occurs in a sex-dependent manner, revealing the existence of different underlying mechanisms of epigenetic modification in male and female mice. | es_ES |
dc.description.sponsorship | This study was supported by grants from the Spanish Health Department ISCIII (DTS 18/00142) and Research Group University of the Basque Country (GI19/018). IM was supported by fellowship from Basque Government and MA and IU were supported by fellowship from the University of the Basque Country (UPV/EHU). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.subject | epigenetic changes | es_ES |
dc.subject | DNA methylation/hydroxymethylation | es_ES |
dc.subject | histone modification | es_ES |
dc.subject | morphine chronic exposure | es_ES |
dc.title | Sex dependent alteration of epigenetic marks after chronic morphine treatment in mice organs | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license
(http://creativecommons.org/licenses/by-nc-nd/4.0/) | es_ES |
dc.rights.holder | Atribución-NoComercial-SinDerivadas 3.0 España | * |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0278691521002337 | es_ES |
dc.identifier.doi | 10.1016/j.fct.2021.112200 | |
dc.departamentoes | Fisiología | es_ES |
dc.departamentoeu | Fisiologia | es_ES |