Examinar INVESTIGACIÓN por departamento (eus.) "Kimika organikoa II"
Now showing items 21-40 of 99
-
Enantioselective Oxidative (4+3) Cycloadditions between Allenamides and Furans through Bifunctional Hydrogen-Bonding/Ion-Pairing Interactions
(Wiley-VCH, 2017-07-03)BINOL-based N-trifluoromethanesulfonyl phosphoramides catalyze the enantioselective (4+3) cycloaddition between furans and oxyallyl cations, the latter being generated in situ by oxidation of allenamides. The chiral ... -
Enantioselective Synthesis of Tropanes: Brønsted Acid Catalyzed Pseudotransannular Desymmetrization
(Wiley-VCH, 2020-02-10)The enantioselective synthesis of tropanols has been accomplished through chiral phosphoric acid catalyzed pseudotransannular ring opening of 1-aminocyclohept-4-ene-derived epoxides. The reaction proceeds together with the ... -
Exploring new labelling strategies for boronated compounds: towards fast development and efficient assessment of BNCT drug candidates
(2015-10-28)La terapia por captura de neutrones (BNCT o Boron Neutron Capture Therapy), fue descrita por primera vez por Locher en 1936 y es una modalidad terapéutica binaria para el tratamiento del cáncer que se basa en la captura ... -
Favoring Trienamine Activation through Unconjugated Dienals: Organocatalytic Enantioselective Remote Functionalization of Alkenes
(Wiley-VCH, 2014-01-29)Unconjugated 2,5-dienals are more reactive substrates than the corresponding fully conjugated a,b,g,dunsaturated aldehydes towards organocatalytic activation through trienamine intermediates. This difference in ... -
Fluorinated carbohydrates as chemical probes formolecular recognition studies. Current statusand perspectives
(Royal Society of Chemistry, 2020-06-21)This review provides an extensive summary of the effects of carbohydrate fluorination with regard to changes in physical, chemical and biological properties with respect to regular saccharides. The specific structural, ... -
Fluorinated Carbohydrates as Lectin Ligands: Simultaneous Screening of a Monosaccharide Library and Chemical Mapping by F-19 NMR Spectroscopy
(American Chemical Society, 2020-12-18)Molecular recognition of carbohydrates is a key step in essential biological processes. Carbohydrate receptors can distinguish monosaccharides even if they only differ in a single aspect of the orientation of the hydroxyl ... -
Fluorine Labeling of Nanoparticles and In Vivo 19F Magnetic Resonance Imaging
(American Chemical Society, 2021-03-24)Fluorinated nanoparticles have increasing applications, but they are still challenging to prepare, especially in the case of water-soluble fluorinated nanoparticles. Herein, a fluorine labeling strategy is presented that ... -
Galectin-4 N-Terminal Domain: Binding Preferences Toward A and B Antigens with Different Peripheral Core Presentations
(Frontiers Media, 2021-04-21)The tandem-repeat Galectin-4 (Gal-4) contains two different domains covalently linked through a short flexible peptide. Both domains have been shown to bind preferentially to A and B histo blood group antigens with different ... -
Gene Prioritization, Communality Analysis, Networking and Metabolic Integrated Pathway to Better Understand Breast Cancer Pathogenesis
(Nature Publishing Group, 2018-11-12)Consensus strategy was proved to be highly efficient in the recognition of gene-disease association. Therefore, the main objective of this study was to apply theoretical approaches to explore genes and communities directly ... -
Generation of Tertiary and Quaternary Stereocenters via Palladium-Catalyzed Intramolecular Heck-type Reactions for the Stereocontrolled Synthesis of Pyrrolo[1,2-b]isoquinolines
(Wiley, 2016-04-05)The generation of quaternary and tertiary stereocenters on C-10 of the pyrroloisoquinoline skeleton through intramolecular Mizoroki-Heck reactions of 2-alkenyl substituted pyrroles and pyrrolidines has been studied. The ... -
Glycan structures and their interactions with proteins. A NMR view
(Elsevier, 2019-12)Carbohydrate molecules are essential actors in key biological events, being involved as recognition points for cell-cell and cell-matrix interactions related to health and disease. Despite outstanding advances in cryoEM, ... -
Glycans in drug discovery
(Royal Soc Chemistry, 2019-07-26)Glycans are key players in many biological processes. They are essential for protein folding and stability and act as recognition elements in cell-cell and cell-matrix interactions. Thus, being at the heart of medically ... -
Glycosyl Oxocarbenium Ions: Structure, Conformation, Reactivity, and Interactions
(American Chemical Society, 2021-06-01)Conspectus We also highlight that, from a chemical perspective, the glycosylation reaction can be described as a continuum, from unimolecular SN1 with naked oxocarbenium cations as intermediates to bimolecular SN2-type ... -
Hydrazides and hydrazones as versatile Michael-Donors for iminium-catalyzed conjugate addition reactions
(2014-02-06)In the work compiled in this thesis is presented a series of strategies that have been studied and have lead to the asymmetric synthesis of useful building blocks in high yields and stereochemical control. These are reliant ... -
Hypoxia Reduces Cell Attachment of SARS-CoV-2 Spike Protein by Modulating the Expression of ACE2, Neuropilin-1, Syndecan-1 and Cellular Heparan Sulfate
(Taylor & Francis, 2021-06-06)A main clinical parameter of COVID-19 pathophysiology is hypoxia. Here we show that hypoxia decreases the attachment of the receptor-binding domain (RBD) and the S1 subunit (S1) of the spike protein of SARS-CoV-2 to ... -
Inter- and intramolecular enantioselective carbolithiation reactions
(Beilstein Institut, 2013-02)In this review we summarize recent developments in inter- and intramolecular enantioselective carbolithiation reactions carried out in the presence of a chiral ligand for lithium, such as (-)-sparteine, to promote facial ... -
Intramolecular Addition of Heteroaryllithiums onto Activated Alkenes. Access to Heterofused Indolizines and Pyrroloazepines
(Wiley, 2017-02-23)Heteroaryllithiums, obtained via MesLi mediated halogen- lithium exchange, undergo intramolecular addition onto acrylamide and acrylate moieties. Both electron rich (thiophenyl) and electron deficient (pyridinyl, quinolinyl) ... -
Intramolecular Mizoroki-Heck reaction in the synthesis of heterocycles. Strategies for the generation of tertiary and quaternary stereocenters
(Societa Chimica Italiana, 2019-02)The intramolecular Mizoroki-Heck (M-H) reaction is a powerful carbon-carbon bond-forming process for the construction of small and medium-size carbocycles and heterocycles. Different strategies have been developed to avoid ... -
Intramolecular Palladium(II)-catalyzed 6-endo C-H alkenylation directed by the remote N-protecting group. Mechanistic insight and application to the synthesis of dihydroquinolines
(American Chemical Society, 2019-12-30)A protocol for the Pd(II)-catalyzed C-H alkenylation reaction of substituted N-allylanilines via an unusual 6-endo process has been developed. A DFT study of the mechanistic pathway has shown that the coordination of the ... -
Ion-pairing catalysis in the enantioselective addition of hydrazones to N-acyldihydropyrrole derivatives
(Royal Society of Chemistry, 2018-07-16)We have demonstrated that dihydropyrrole-based enamide derivatives can act as efficient precursors of chiral quaternary N-acyliminium salts under Brønsted acid catalysis that undergo reactions with hydrazones, the latter ...