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Editorial: Tumor microenvironment in primary brain cancers
(Frontiers, 2023-01-24)
Primary brain tumors are most commonly detected in the late stages of the disease and there are only a few treatment opportunities. Overall survival rates are significantly low and the response to chemo/radiotherapy is not ...
Improving the Antitumor Effect of Chemotherapy with Ocoxin as a Novel Adjuvant Agent to Treat Prostate Cancer
(MDPI, 2023-05-29)
Prostate cancer is one of the most common cancers among men. Although many patients respond favorably to first-line treatments, castration—and chemotherapy—resistance arises after a few years, leading to metastasis. Thus, ...
The Long-Term Neuroprotective Effect of the Endocannabinoid 2-AG and Modulation of the SGZ’s Neurogenic Response after Neonatal Hypoxia-Ischemia
(MDPI, 2023-06-07)
Neonatal hypoxia-ischemia (HI) often causes hypoxic-ischemic encephalopathy (HIE), a neurological condition that can lead to overall disability in newborns. The only treatment available for affected neonates is therapeutic ...
Enhanced Adipogenic Differentiation of Human Dental Pulp Stem Cells in Enzymatically Decellularized Adipose Tissue Solid Foams
(MDPI, 2022-07-23)
Engineered 3D human adipose tissue models and the development of physiological human 3D in vitro models to test new therapeutic compounds and advance in the study of pathophysiological mechanisms of disease is still ...
Computational and Experimental Evaluation of the Immune Response of Neoantigens for Personalized Vaccine Design
(MDPI, 2023-05-19)
In the last few years, the importance of neoantigens in the development of personalized antitumor vaccines has increased remarkably. In order to study whether bioinformatic tools are effective in detecting neoantigens that ...
Stem Cell Therapy and Rejuvenation, and Their Impact on Society
(MDPI, 2023-06-07)
n his worldwide best-seller Homo Deus [1], historian and philosopher Yuval Noah Harari discusses the future challenges facing humankind. In particular, he predicts that humanity will pursue three goals in the coming decades: ...
The domestic dog that lived ∼17,000 years ago in the Lower Magdalenian of Erralla site (Basque Country): A radiometric and genetic analysis
(Elsevier, 2022-12)
Dogs are known to be the first species domesticated by humans, although the geographic and temporal origin of this process is still under debate in different fields of knowledge. In the present study, we examined a humerus ...
BRAF V600E mutational load as a prognosis biomarker in malignant melanoma
(Public Library Science, 2020-03-13)
Analyzing the mutational load of driver mutations in melanoma could provide valuable information regarding its progression. We aimed at analyzing the heterogeneity of mutational load of BRAF V600E in biopsies of melanoma ...
RKIP Regulates Differentiation-Related Features in Melanocytic Cells
(MDPI, 2020-06-03)
Raf Kinase Inhibitor Protein (RKIP) has been extensively reported as an inhibitor of keysignaling pathways involved in the aggressive tumor phenotype and shows decreased expressionin several types of cancers. However, ...
Serum markers improve current prediction of metastasis development in early-stage melanoma patients: a machine learning-based study
(Wiley, 2020-06)
Metastasis development represents an important threat for melanoma patients, even when diagnosed at early stages and upon removal of the primary tumor. In this scenario, determination of prognostic biomarkers would be of ...