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Citocinas proinflamatorias: participación en la modulación de la actividad del melanoma experimental B16
(2014-09-12)
[ES]El melanoma es una enfermedad tumoral que se caracteriza por su alto potencial de agresividad y capacidad metastática. Su evolución con frecuencia es imprevisible y su incidencia está aumentando más rápidamente que la ...
Uptake and intracytoplasmic storage of pigmented particles by human CD34+stromal cells/telocytes: endocytic property of telocytes
(Wiley Blackwell, 2014-12)
We studied the phagocytic-like capacity of human CD34+ stromal cells/telocytes (TCs). For this, we examined segments of the colon after injection of India ink to help surgeons localize lesions identified at endoscopy. Our ...
Perinatal hipoxic ischemic injury in the auditory pathway and the effect of several neuroprotective agents
(2015-10-16)
Despite improvements in neonatology, perinatal hypoxic-ischemic (HI) encephalopathy remains one of the main causes of disabilities in term-born infants. This specific pathology underlies many neurological disorders such ...
The Interplay between Natural Selection and Susceptibility to Melanoma on Allele 374F of SLC45A2 Gene in a South European Population
(Public Library Science, 2014-08-05)
We aimed to study the selective pressures interacting on SLC45A2 to investigate the interplay between selection and susceptibility to disease. Thus, we enrolled 500 volunteers from a geographically limited population ...
Resveratrol prevents inflammation-dependent hepatic melanoma metastasis by inhibiting the secretion and effects of interleukin-18
(BioMed Central, 2011-05)
Background: Implantation and growth of metastatic cancer cells at distant organs is promoted by inflammation-dependent mechanisms. A hepatic melanoma metastasis model where a majority of metastases are generated via ...
Vascular endothelial growth factor regulates melanoma cell adhesion and growth in the bone marrow microenvironment via tumor cyclooxygenase-2
(BioMed Central, 2011-08)
Background: Human melanoma frequently colonizes bone marrow (BM) since its earliest stage of systemic dissemination, prior to clinical metastasis occurrence. However, how melanoma cell adhesion and proliferation mechanisms ...
Growth, reproduction and recruitment of Eisenia andrei in natural substrates: A functional approach
(2016-12-16)
En esta tesis se realiza un estudio de la respuesta fisiológica de individuos de la especie de lombriz epigea Eisenia andrei sometidos a distintas condiciones de cultivo en substratos naturales. Uno de los parámetros a ...
Influencia de las células madre mesenquimales en la recuperación de oligodendrocitos sometidos a estrés oxidativo
(Servicio Editorial de la Universidad del País Vasco/Euskal Herriko Unibertsitatearen Argitalpen Zerbitzua, 2014-03-04)
La integridad de la mielina en el sistema nervioso central (SNC) depende directamente de la estabilidad de las células responsables de su formación, los oligodendrocitos, cuya funcionalidad se ve reducida, en gran medida, ...
α2,3-Sialyltransferase ST3Gal III Modulates Pancreatic Cancer Cell Motility and Adhesion In Vitro and Enhances Its Metastatic Potential In Vivo
(Public Library of Science, 2010-09-01)
Background: Cell surface sialylation is emerging as an important feature of cancer cell metastasis. Sialyltransferase expression has been reported to be altered in tumours and may account for the formation of sialylated ...
Efecto antitumoral de la terfenadina, antagonista del receptor H1 de la histamina, mediado por el complejo I mitocondrial
(2015-07-10)
El cáncer es una de las principales causas de muerte a escala mundial y un problema de salud prioritario. Cada año la incidencia del cáncer aumenta, y a pesar de que la mortalidad disminuye gracias a los avances en el ...