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Leukemia-Associated Mutations in Nucleophosmin Alter Recognition by CRM1: Molecular Basis of Aberrant Transport
(Public Library of Science, 2015-06-19)
Nucleophosmin (NPM) is a nucleocytoplasmic shuttling protein, normally enriched in nucleoli, that performs several activities related to cell growth. NPM mutations are characteristic of a subtype of acute myeloid leukemia ...
Structural studies of the hipersaline adaptation of proteins belonging to halophilic archaea
(2015-10-05)
Adaptation of organisms to extreme halophilic environments (> 1 ¿ 2 M) occurs through theaccumulation of large intracellular concentrations of KCl. Their major adaptive feature is theextensive modification of the constituting ...
Structural characterization of helices A and B of Kv7.2 channel bound to Calmodulin. The calcium effect
(2015-12-15)
Los canales neuronales heterodiméricos Kv7.2 y Kv7.3 son el sustrato molecular de la corriente depotasio no-inactivante dominada ¿Corriente M¿. Ésta juega un papel crítico en el control de laexcitabilidad neuronal. Su mal ...
Sphingomyelinase D/Ceramide 1-Phosphate in Cell Survival and Inflammation
(MDPI, 2015-05)
Sphingolipids are major constituents of biological membranes of eukaryotic cells. Many studies have shown that sphingomyelin (SM) is a major phospholipid in cell bilayers and is mainly localized to the plasma membrane of ...
Development of soft and rigid membrane nanotemplates for the mechanistic analysis of Dynamin I action on curved surfaces
(2015-03-26)
En los últimos años se ha ido desvelando el rol activo de la curvaturade membrana en los procesos de reorganización de membranas celulares. Lamayoría de las membranas celulares presentan una cierta curvatura; dichacurvatura ...
Proteomic Analysis of the Ubiquitin Landscape in the Drosophila Embryonic Nervous System and the Adult Photoreceptor Cells
(Public Library Science, 2015-10-13)
Background
Ubiquitination is known to regulate physiological neuronal functions as well as to be involved in a number of neuronal diseases. Several ubiquitin proteomic approaches have been developed during the last ...
Seroprevalence of Triatoma virus (Dicistroviridae: Cripaviridae) antibodies in Chagas disease patients
(Biomed Central, 2015-01-17)
Background: Chagas disease is caused by Trypanosoma cruzi, and humans acquire the parasite by exposure to contaminated feces from hematophagous insect vectors known as triatomines. Triatoma virus (TrV) is the sole viral ...
Adenylate Cyclase Toxin promotes bacterial internalisation into non phagocytic cells
(Nature Publishing Group, 2015-09-08)
Bordetella pertussis causes whooping cough, a respiratory infectious disease that is the fifth largest cause of vaccine-preventable death in infants. Though historically considered an extracellular pathogen, this bacterium ...
Membrane activities of Dynamin-related protein 1 (DRP1) and BCL2-related Ovarian Killer (BOK)
(2015-03-27)
BCL2 familiako proteinek heriotz zelular programatua (apoptosia) mitokondriako kanpo mintzeko iragazkortasuna modulatuz erregulatzen dute. BCL2 familiako proteinak bi talde nagusitan bana daitezke funtzioaren arabera: kide ...