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Mediterranean diet and quality of life: Baseline cross-sectional analysis of the PREDIMED-PLUS trial
(Public Libray fo Science, 2018-06-18)
We assessed if a 17-item score capturing adherence to a traditional Mediterranean diet (MedDiet) was associated with better health-related quality of life among older Spanish men and women with overweight or obesity harboring ...
Acute depletion of diacylglycerol from the cis -Golgi affects localized nuclear envelope morphology during mitosis
(American Society for Biochemistry and Molecular Biology, 2018-08)
Dysregulation of nuclear envelope (NE) assembly results in various cancers; for example, renal and some lung carcinomas ensue due to NE malformation. The NE is a dynamic membrane compartment and its completion during mitosis ...
Open questions and misconceptions in the diagnosis and management of anemia in patients with gastrointestinal bleeding
(Elsevier, 2018-01)
Despite high prevalence of iron deficiency anemia (IDA) in patients with acute or chronic gastrointestinal bleeding (GIB), IDA and iron deficiency (ID) are frequently untreated. Reasons may be misconceptions about the ...
A new approach to epigenome-wide discovery of non-invasive methylation biomarkers for colorectal cancer screening in circulating cell-free DNA using pooled samples
(Biomed Central, 2018-04-16)
Background: Colorectal cancer is the fourth cause of cancer-related deaths worldwide, though detection at early stages associates with good prognosis. Thus, there is a clear demand for novel non-invasive tests for the early ...
Colorectal cancer molecular classification using BRAF, KRAS, microsatellite instability and CIMP status: Prognostic implications and response to chemotherapy
(Public Library of Science, 2018-09-06)
Objective
The aim of this study was to validate a molecular classification of colorectal cancer (CRC) based on microsatellite instability (MSI), CpG island methylator phenotype (CIMP) status, BRAF, and KRAS and investigate ...
Symptom or faecal immunochemical test based referral criteria for colorectal cancer detection in symptomatic patients: a diagnostic tests study
(Biomed Central, 2018-10-25)
BackgroundSymptom based referral criteria for colorectal cancer (CRC) detection are the cornerstone of the strategy to improve prognosis in CRC. In 2017, the National Institute for Health and Care Excellence (NICE) updated ...
Transcription Factor Binding Site Enrichment Analysis In Co-Expression Modules In Celiac Disease
(MDPI, 2018-05-10)
The aim of this study was to construct celiac co-expression patterns at a whole genome level and to identify transcription factors (TFs) that could drive the gliadin-related changes in coordination of gene expression ...
Functional recovery in patients with schizophrenia: recommendations from a panel of experts
(Biomed Central, 2018-06-05)
emission and encompasses multiple aspects of the patient's life, making it difficult to settle on a definition and to develop reliable assessment criteria. In this consensus process based on a panel of experts in schizophrenia, ...
Extracellular Vesicles in Hepatobiliary Malignancies
(Frontiers Media, 2018-10-12)
Primary hepatobiliary malignancies include a heterogeneous group of cancers with dismal prognosis, among which hepatocellular carcinoma (HCC), cholangiocarcinoma (CCA), and hepatoblastoma (HB) stand out. These tumors mainly ...
Temporal trends in hyperuricaemia in the Irish health system from 2006-2014: A cohort study
(Public Library Science, 2018-05-31)
Background
Elevated serum uric acid (sUA) concentrations are common in the general population and are associated with chronic metabolic conditions and adverse clinical outcomes. We evaluated secular trends in the burden ...