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Integrated treatment of first episode psychosis with online training (e-learning): study protocol for a randomised controlled trial
(Biomed Central, 2014-10-27)
Background: The integrated treatment of first episode psychosis has been shown to improve functionality and negative symptoms in previous studies. In this paper, we describe a study of integrated treatment (individual ...
Morphofunctional changes in a rat model of Parkinson's disease - Effects of neurotrophic factors administration
(2015-10-02)
La investigación actual se basa en la búsqueda de estrategias terapéuticas que consigan detener el proceso neurodegenerativo de la enfermedad de Parkinson. Por tanto, la administración de factores neurotróficos puede ser ...
Bipolar disorder comorbid with alcohol use disorder: Focus on neurocognitive correlates
(Frontiers Research Foundation, 2015-04-07)
Bipolar disorder (BD) and alcohol use disorders (AUDs) are usually comorbid, and both have been associated with significant neurocognitive impairment. Patients with the BD-AUD comorbidity (dual diagnosis) may have more ...
Never-resting microglia: physiological roles in the healthy brain and pathological implications
(Frontiers Research Foundation, 2014-08-15)
Microglia are largely known as the major orchestrators of the brain inflammatory response. As such, they have been traditionally studied in various contexts of disease, where their activation has been assumed to induce a ...
Radiotherapy plus nimotuzumab or placebo in the treatment of high grade glioma patients: results from a randomized, double blind trial
(BioMed Central, 2013-06-19)
Background
The prognosis of patients bearing high grade glioma remains dismal. Epidermal Growth Factor Receptor (EGFR) is well validated as a primary contributor of glioma initiation and progression. Nimotuzumab is a ...
Plasma brain-derived neurotrophic factor levels, learning capacity and cognition in patients with first episode psychosis
(BioMed Central, 2013)
Background: Cognitive impairments are seen in first psychotic episode (FEP) patients. The neurobiological underpinnings that might underlie these changes remain unknown. The aim of this study is to investigate whether
Brain ...
Factors associated with chronic pain in patients with bipolar depression: a cross-sectional study
(BioMed Central, 2013-04-15)
Background: While pain is frequently associated with unipolar depression, few studies have investigated the link between pain and bipolar depression. In the present study we estimated the prevalence and characteristics of ...
Antioxidant defense system and family environment in adolescents with family history of psychosis
(BioMed Central, 2012-11-16)
[EN] Our objective was to determine antioxidant defence activity in healthy controls (HC) and healthy unaffected second-degree relatives of patients with early onset psychosis (HC-FHP),and to assess its relationship with ...
Enfermedad de Parkinson por mutación vasca de la dardarina (LRRK2): estudio epidemiológico, clínico y genético
(Servicio Editorial de la Universidad del País Vasco/Euskal Herriko Unibertsitatearen Argitalpen Zerbitzua, 2012-06-22)
La genética ha cobrado un papel primordial en la etiopatogenia de la enfermedad de Parkinson (EP), especialmente tras el descrubrimiento en 2004 de las primeras mutaciones en el gen LRRK2, que codifica la proteína denominada ...
Arquitectura subcelular del sistema endocannabinoide en el núcleo ventromedial del hipotálamo de ratón
(2014-01-30)
El sistema endocannabinoide (eCB) es un complejo sistema endógeno de señalización, que participa en la modulación de la transmisión sináptica en múltiples circuitos cerebrales, incluyendo los que regulan el apetito, ingesta ...