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Co-administration of Anti microRNA-124 and -137 Oligonucleotides Prevents Hippocampal Neural Stem Cell Loss Upon Non-convulsive Seizures

Bielefeld, Pascal; Schouten, Marijn; Meijer, Guido M.; Breuk, Marit J.; Geijtenbeek, Karlijne; Karayel, Sedef; Tiaglik, Alisa; Vuuregge, Anna H.; Willems, Ruth A.L.; Witkamp, Diede; Lucassen, Paul J.; Encinas Pérez, Juan Manuel; Fitzsimons, Carlos P. (Frontiers Media, 2019-02-19)

Convulsive seizures promote adult hippocampal neurogenesis (AHN) through a transient activation of neural stem/progenitor cells (NSPCs) in the subgranular zone (SGZ) of the dentate gyrus (DG). However, in a significant ...

Circadian glucocorticoid oscillations preserve a population of adult hippocampal neural stem cells in the aging brain

Schouten, Marijn; Bielefeld, Pascal; García Corzo, L.; Passchier, E. M. J.; Gradari, S.; Jungenitz, T.; Pons Espinal, M.; Gebara, E.; Martín Suárez, Soraya; Lucassen, Paul J.; De Vries, H. E.; Trejo Pérez, Jose Luis; Schwarzacher, S. W.; De Pietri Tonelli, D.; Toni, N.; Mira, H.; Encinas Pérez, Juan Manuel; Fitzsimons, Carlos P. (Springer, 2019-06-20)

A decrease in adult hippocampal neurogenesis has been linked to age-related cognitive impairment. However, the mechanisms involved in this age-related reduction remain elusive. Glucocorticoid hormones (GC) are important ...

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Co-administration of Anti microRNA-124 and -137 Oligonucleotides Prevents Hippocampal Neural Stem Cell Loss Upon Non-convulsive Seizures

Circadian glucocorticoid oscillations preserve a population of adult hippocampal neural stem cells in the aging brain