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Fine-Tuning of Sirtuin 1 Expression Is Essential to Protect the Liver From Cholestatic Liver Disease
(Wiley, 2019-02)
Cholestasis comprises aetiologically heterogeneous conditions characterized by accumulation of bile acids in the liver that actively contribute to liver damage. Sirtuin 1 (SIRT1) regulates liver regeneration and bile acid ...
Determinación del valor pronóstico y predictivo de respuesta a temozolomida de la metilación del promotor de MGMT en pacientes con gliomas de alto grado tratados en el Hospital Universitario de Donostia
(2019-06-07)
El glioblastoma multiforme (GBM) es el tumor primario más frecuente del sistema nervioso central (SNC). El pronóstico de estos tumores es infausto: con el actual tratamiento estándar ¿que consiste en cirugía seguida de ...
Extracellular Vesicles in Liver Diseases: Meeting Report from the International Liver Congress 2018
(Wiley, 2019-02)
Extracellular vesicles (EVs) are small and heterogeneous membrane-bound structures released by cells and found in all biological fluids. They are effective intercellular communicators, acting on a number of close and/or ...
Adaptive Downregulation of Cl-/HCO3- Exchange Activity in Rat Hepatocytes under Experimental Obstructive Cholestasis
(Public Library Science, 2019-02-21)
In obstructive cholestasis, there is an integral adaptive response aimed to diminish the bile flow and minimize the injury of bile ducts caused by increased intraluminal pressure and harmful levels of bile salts and ...
Eficacia de un Programa Multidisciplinar de Gestión de Cuidados en Pacientes que Ingresan por Insuficiencia Cardiaca (ProMIC)
(Doyma, 2019-03)
Objetivo:
Evaluar
la
eficacia
de
«
ProMIC
»
,
programa
multidisciplinar
de
atención
a
pacientes
con
insuficiencia
cardiaca
(IC),
para
reducir
de
la
tasa
de
reingresos
por
IC.
Dise
̃
no:
En ...
Burkitt-like lymphoma with 11q aberration: a germinal center-derived lymphoma genetically unrelated to Burkitt lymphoma
(Ferrata Storti Foundation, 2019-08-31)
Burkitt-like lymphoma with 11q aberration is characterized by pathological features and gene expression profile resembling those of Burkitt lymphoma but lacks the MYC rearrangement and carries an 11q-arm aberration with ...
Brain connectivity and cognitive functioning in individuals six months after multiorgan failure
(Elsevier, 2019-12)
Abstract
Multiorgan failure (MOF) is a life-threating condition that affects two or more systems of organs not involved in the disorder that motivates admission to an Intensive Care Unit (ICU). Patients who survive MOF ...
La monitorización continua del nervio recurrente durante la tiroidectomía.
(2019-11-05)
Actualmente, la principal complicación de la tiroidectomía es la lesión del nervio laríngeo inferior o recurrente. Las secuelas pueden ser dificultades deglutorias, afonía o en los casos más graves, la necesidad de una ...
Gut microbiome and serum metabolome analyses identify molecular biomarkers and altered glutamate metabolism in fibromyalgia
(Elsevier, 2019-08)
Background: Fibromyalgia is a complex, relatively unknown disease characterised by chronic, widespread musculoskeletal pain. The gut-brain axis connects the gut microbiome with the brain through the enteric nervous system ...
Broad Phenotypes of Disorders/Differences of Sex Development in MAMLD1 Patients Through Oligogenic Disease
(Frontiers Media, 2019-08-29)
Disorders/differences of sex development (DSD) are the result of a discordance between chromosomal, gonadal, and genital sex. DSD may be due to mutations in any of the genes involved in sex determination and development ...